HCSGD entry for LAYN
1. General information
| Official gene symbol | LAYN |
|---|---|
| Entrez ID | 143903 |
| Gene full name | layilin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | ISS | cellular_component |
| GO:0005540 | Hyaluronic acid binding | IDA | molecular_function |
| GO:0005925 | Focal adhesion | ISS | cellular_component |
| GO:0009986 | Cell surface | ISS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9630805365 | 0.0017203602 | 0.9999902473 | 0.0794414035 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2826463140 |
| GSE13712_SHEAR | Down | -0.1073093371 |
| GSE13712_STATIC | Down | -0.1139650977 |
| GSE19018 | Up | 0.0998305670 |
| GSE19899_A1 | Down | -1.1643462985 |
| GSE19899_A2 | Down | -1.3024152653 |
| PubMed_21979375_A1 | Down | -2.6577006356 |
| PubMed_21979375_A2 | Down | -1.4125726391 |
| GSE35957 | Up | 0.4181199481 |
| GSE36640 | Down | -1.3031482613 |
| GSE54402 | Down | -1.6387738862 |
| GSE9593 | Up | 0.4889668247 |
| GSE43922 | Down | -1.0497936773 |
| GSE24585 | Down | -0.1372435442 |
| GSE37065 | Up | 0.0449597428 |
| GSE28863_A1 | Down | -0.1831025883 |
| GSE28863_A2 | Down | -0.2133464696 |
| GSE28863_A3 | Down | -0.1285490895 |
| GSE28863_A4 | Down | -0.3401196119 |
| GSE48662 | Up | 0.3052627041 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Hyaluronic acid | DB08818 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21740549 | Comparison of these known targets with genes known to be up-regulated upon senescence in these cells, by micro-array expression profiling, identified 4 common genes TMEM9B, ATXN10, LAYN and LTBP2/3 |
| 21740549 | CONCLUSION: The senescence bypass screen identified TMEM9B, ATXN10, LAYN and LTBP2/3 as novel downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways |
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