HCSGD entry for CSF1

1. General information

Official gene symbolCSF1
Entrez ID1435
Gene full namecolony stimulating factor 1 (macrophage)
Other gene symbolsCSF-1 MCSF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionIEA ISSbiological_process
GO:0002158Osteoclast proliferationIEAbiological_process
GO:0003006Developmental process involved in reproductionIEA ISSbiological_process
GO:0005125Cytokine activityIDA IEAmolecular_function
GO:0005157Macrophage colony-stimulating factor receptor bindingIEA ISS TASmolecular_function
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0008083Growth factor activityIDA IEA NASmolecular_function
GO:0008283Cell proliferationNASbiological_process
GO:0008284Positive regulation of cell proliferationIDA TASbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010743Regulation of macrophage derived foam cell differentiationNASbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0016020MembraneNAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030097HemopoiesisNASbiological_process
GO:0030154Cell differentiationNASbiological_process
GO:0030225Macrophage differentiationIEA TASbiological_process
GO:0030278Regulation of ossificationIEAbiological_process
GO:0030316Osteoclast differentiationIDA IEAbiological_process
GO:0030335Positive regulation of cell migrationIEA ISSbiological_process
GO:0032270Positive regulation of cellular protein metabolic processIDAbiological_process
GO:0032946Positive regulation of mononuclear cell proliferationIDAbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0042117Monocyte activationNASbiological_process
GO:0042476OdontogenesisIEAbiological_process
GO:0042488Positive regulation of odontogenesis of dentin-containing toothIEAbiological_process
GO:0042803Protein homodimerization activityIDA IEAmolecular_function
GO:0043235Receptor complexIEA ISScellular_component
GO:0045087Innate immune responseIEAbiological_process
GO:0045651Positive regulation of macrophage differentiationIDA IEAbiological_process
GO:0045657Positive regulation of monocyte differentiationIEA ISSbiological_process
GO:0045672Positive regulation of osteoclast differentiationIDA IEAbiological_process
GO:0045860Positive regulation of protein kinase activityIEA ISSbiological_process
GO:0046579Positive regulation of Ras protein signal transductionIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060611Mammary gland fat developmentIEAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09550696400.30976236090.64724160661.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0608995601
GSE13712_SHEARDown-0.0756412891
GSE13712_STATICUp0.0179467079
GSE19018Up0.0903462566
GSE19899_A1Down-0.0961900041
GSE19899_A2Down-0.2793404594
PubMed_21979375_A1Down-0.5358993319
PubMed_21979375_A2Down-0.0275382991
GSE35957Up0.6082761794
GSE36640Up0.2746862528
GSE54402Down-0.4549512865
GSE9593Up0.4737703191
GSE43922Down-0.6365257621
GSE24585Down-0.2230454466
GSE37065Up0.5234403829
GSE28863_A1Up1.0659145093
GSE28863_A2Up1.2766723346
GSE28863_A3Down-0.0800489256
GSE28863_A4Down-0.1987855573
GSE48662Up0.3424832966

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-130a-3pMIMAT0000425MIRT004575Luciferase reporter assay//Reporter assayFunctional MTI14697198
hsa-miR-130a-3pMIMAT0000425MIRT004575Luciferase reporter assay//Western blotFunctional MTI18823650
hsa-miR-130b-3pMIMAT0000691MIRT006200ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI22005523
hsa-miR-148b-3pMIMAT0000759MIRT007318Western blotFunctional MTI23238785
hsa-miR-335-5pMIMAT0000765MIRT016979MicroarrayFunctional MTI (Weak)18185580
hsa-miR-505-3pMIMAT0002876MIRT041071CLASHFunctional MTI (Weak)23622248
hsa-miR-30b-5pMIMAT0000420MIRT046121CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047860CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-130a-3pMIMAT00004251hsa-miR-130a{activity assay}{luciferase}14697198
hsa-miR-130a-3pMIMAT00004252hsa-miR-130a{activity assay}{luciferase}14697198
hsa-miR-130a-3pMIMAT0000425NAhsa-miR-130a18823650
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26025293The concentration of proinflammatory SASP markers (granulocyte macrophage colony-stimulating factor, interleukin-6 and -8) was significantly higher in the amniotic fluid of women in labor at term than women not in labor
16419088We report that vitamin E induces dramatic microglial proliferation, as measured by MTT assay and BrdU incorporation, surpassing that of the well-known microglial mitogen granulocyte macrophage-colony stimulating factor, and therefore establishing vitamin E as the most potent, known mitogen for microglia in vitro
8806439Under conditions of IL-1 noninduction, messenger RNA expression levels of macrophage colony-stimulating factor (M-CSF) were three times higher in non-S-phase cells of young cultures than those in S-phase cells
8806439Under conditions of IL-1 induction G-CSF and M-CSF expression levels were enhanced in both young and old cells
8806439Significant M-CSF product was detected in young cells but not in old cells, whereas G-CSF product increased dramatically in both types of cells
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