HCSGD entry for CS
1. General information
| Official gene symbol | CS |
|---|---|
| Entrez ID | 1431 |
| Gene full name | citrate synthase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004108 | Citrate (Si)-synthase activity | IDA IEA TAS | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | IDA | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046912 | Transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8340112382 | 0.1438919836 | 0.9999902473 | 0.7307314104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0607812686 |
| GSE13712_SHEAR | Down | -0.2717889105 |
| GSE13712_STATIC | Down | -0.0701375110 |
| GSE19018 | Down | -0.2289126504 |
| GSE19899_A1 | Down | -0.1568810990 |
| GSE19899_A2 | Up | 0.1852911308 |
| PubMed_21979375_A1 | Down | -0.0840906052 |
| PubMed_21979375_A2 | Up | 0.6662634553 |
| GSE35957 | Down | -0.4583021050 |
| GSE36640 | Down | -0.3087000431 |
| GSE54402 | Up | 0.3847916890 |
| GSE9593 | Down | -0.3692597827 |
| GSE43922 | Down | -0.0032140111 |
| GSE24585 | Down | -0.1526369988 |
| GSE37065 | Down | -0.1618947147 |
| GSE28863_A1 | Up | 0.0504323283 |
| GSE28863_A2 | Down | -0.1024544380 |
| GSE28863_A3 | Down | -0.0524095134 |
| GSE28863_A4 | Up | 0.0503119504 |
| GSE48662 | Down | -0.2295959961 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Trifluoroacetonyl Coenzyme A | DB01969 | EXPT00982 |
| Coenzyme A | DB01992 | EXPT00991 |
| Oxaloacetate Ion | DB02637 | EXPT02406 |
| Alpha-Fluoro-Carboxymethyldethia Coenzyme a Complex | DB03182 | EXPT01407 |
| Malate Ion | DB03499 | EXPT02188 |
| Nitromethyldethia Coenzyme A | DB04230 | EXPT02369 |
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032306 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7a-3p | MIMAT0004481 | MIRT039003 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041479 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043140 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT050008 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052406 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15018610 | Uncoupled respiration, as normalized to citrate synthase activity, remained unchanged, reflecting a constant capacity of the respiratory chain |
| 10683163 | In young red blood cells, the activities of the mitochondrial enzymes citrate synthase and cytochrome oxidase were 135-200 %, respectively, of those measured in old red blood cells |
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