HCSGD entry for CREBL2
1. General information
| Official gene symbol | CREBL2 |
|---|---|
| Entrez ID | 1389 |
| Gene full name | cAMP responsive element binding protein-like 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045600 | Positive regulation of fat cell differentiation | ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0046326 | Positive regulation of glucose import | ISS | biological_process |
| GO:0046889 | Positive regulation of lipid biosynthetic process | ISS | biological_process |
| GO:0050821 | Protein stabilization | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0768780365 | 0.9273455796 | 0.5860199363 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1201307282 |
| GSE13712_SHEAR | Down | -0.1351254940 |
| GSE13712_STATIC | Down | -0.2051747690 |
| GSE19018 | Up | 0.5647193960 |
| GSE19899_A1 | Down | -0.1045054403 |
| GSE19899_A2 | Up | 0.3280065295 |
| PubMed_21979375_A1 | Down | -0.1243585144 |
| PubMed_21979375_A2 | Up | 0.0505056380 |
| GSE35957 | Up | 0.5926877444 |
| GSE36640 | Up | 0.7099012564 |
| GSE54402 | Up | 0.2417718264 |
| GSE9593 | Up | 0.6925769648 |
| GSE43922 | Down | -0.0679568237 |
| GSE24585 | Up | 0.4713044433 |
| GSE37065 | Up | 0.0121047699 |
| GSE28863_A1 | Down | -0.0963393742 |
| GSE28863_A2 | Up | 0.2475014161 |
| GSE28863_A3 | Up | 0.0154040612 |
| GSE28863_A4 | Down | -0.0089851441 |
| GSE48662 | Down | -0.2307624751 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000832 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000833 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024903 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026935 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031269 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT031360 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029164 | The mechanism study showed that CSIG modulated the mRNA half-life of Cdc14B, CASP7, and CREBL2 |
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