HCSGD entry for ATF2

1. General information

Official gene symbolATF2
Entrez ID1386
Gene full nameactivating transcription factor 2
Other gene symbolsCRE-BP1 CREB2 HB16 TREB7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0001076RNA polymerase II transcription factor binding transcription factor activityICmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityICmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004402Histone acetyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005741Mitochondrial outer membraneIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterICbiological_process
GO:0006366Transcription from RNA polymerase II promoterICbiological_process
GO:0006970Response to osmotic stressIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDA IMPbiological_process
GO:0008140CAMP response element binding protein bindingIDAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016573Histone acetylationIDAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031573Intra-S DNA damage checkpointIMPbiological_process
GO:0032915Positive regulation of transforming growth factor beta2 productionIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035497CAMP response element bindingIDA IEAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045444Fat cell differentiationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0060612Adipose tissue developmentIEAbiological_process
GO:1902110Positive regulation of mitochondrial membrane permeability involved in apoptotic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78439428590.16067406250.99999024730.7738521500

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0558968092
GSE13712_SHEARUp0.1578170524
GSE13712_STATICDown-0.1796099266
GSE19018Down-0.0007807325
GSE19899_A1Up0.0442116769
GSE19899_A2Down-0.1779102652
PubMed_21979375_A1Down-0.3361052286
PubMed_21979375_A2Down-0.2318860340
GSE35957Down-0.0613685464
GSE36640Down-0.1915812718
GSE54402Up0.0223670516
GSE9593Up0.0117854090
GSE43922Down-0.1385733778
GSE24585Up0.6845304494
GSE37065Up0.0380030286
GSE28863_A1Down-0.0646949449
GSE28863_A2Up0.2565432609
GSE28863_A3Down-0.6723368917
GSE28863_A4Down-0.2852372873
GSE48662Up0.1242754031

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-374b-5pMIMAT0004955MIRT016080SequencingFunctional MTI (Weak)20371350
hsa-miR-335-5pMIMAT0000765MIRT019034MicroarrayFunctional MTI (Weak)18185580
hsa-miR-21-5pMIMAT0000076MIRT031029MicroarrayFunctional MTI (Weak)18591254
hsa-miR-19b-3pMIMAT0000074MIRT031297SequencingFunctional MTI (Weak)20371350
hsa-miR-15a-5pMIMAT0000068MIRT051336CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.