HCSGD entry for CREB1
1. General information
| Official gene symbol | CREB1 |
|---|---|
| Entrez ID | 1385 |
| Gene full name | cAMP responsive element binding protein 1 |
| Other gene symbols | CREB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | molecular_function |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | molecular_function |
| GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | IDA | molecular_function |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA IEA | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003712 | Transcription cofactor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005719 | Nuclear euchromatin | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0008361 | Regulation of cell size | IEA | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010033 | Response to organic substance | IDA | biological_process |
| GO:0010944 | Negative regulation of transcription by competitive promoter binding | IDA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0021983 | Pituitary gland development | IEA | biological_process |
| GO:0033363 | Secretory granule organization | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035497 | CAMP response element binding | IDA | molecular_function |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045600 | Positive regulation of fat cell differentiation | IEA ISS | biological_process |
| GO:0045672 | Positive regulation of osteoclast differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0046887 | Positive regulation of hormone secretion | IEA | biological_process |
| GO:0046889 | Positive regulation of lipid biosynthetic process | IEA ISS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0050821 | Protein stabilization | IEA ISS | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0060430 | Lung saccule development | IEA | biological_process |
| GO:0060509 | Type I pneumocyte differentiation | IEA | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9353962957 | 0.0277722807 | 0.9999902473 | 0.3171341432 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1775560637 |
| GSE13712_SHEAR | Up | 0.0485642291 |
| GSE13712_STATIC | Down | -0.0987273646 |
| GSE19018 | Down | -0.1952239677 |
| GSE19899_A1 | Down | -0.3891519543 |
| GSE19899_A2 | Down | -0.6333886371 |
| PubMed_21979375_A1 | Down | -0.5740938136 |
| PubMed_21979375_A2 | Down | -0.9448529445 |
| GSE35957 | Down | -0.2069550887 |
| GSE36640 | Down | -0.8704594682 |
| GSE54402 | Up | 0.1171278940 |
| GSE9593 | Down | -0.1241024466 |
| GSE43922 | Down | -0.3006298843 |
| GSE24585 | Up | 0.3457937150 |
| GSE37065 | Up | 0.1382555549 |
| GSE28863_A1 | Up | 0.2974741674 |
| GSE28863_A2 | Up | 0.3465966935 |
| GSE28863_A3 | Down | -0.7471555894 |
| GSE28863_A4 | Down | -0.3660491660 |
| GSE48662 | Up | 0.1275091926 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Naloxone | DB01183 | APRD00025 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34b-5p | MIMAT0000685 | MIRT000066 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19258499 |
| hsa-miR-34b-5p | MIMAT0000685 | MIRT000066 | Luciferase reporter assay | Functional MTI | 19461653 |
| hsa-miR-203a | MIMAT0000264 | MIRT006496 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21707582 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT004766 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20886090 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT006273 | GFP reporter assay | Functional MTI | 22325466 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT007342 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23543137 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT007342 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23546867 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023389 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26414604 | ALA stimulated cyclic adenosine monophosphate (cAMP) signaling, which in turn activated the cAMP response element-binding protein (CREB), a co-factor for PGC-1alpha expression |
| 23991634 | Lung aging is associated with morphological and physiological changes in which alterations in transcription factors, including the cyclic adenosine monophosphate response element-binding protein (CREB), could play a role |
| 23991634 | We studied CREB in lung tissue from mice at different ages and in response to known age-related factors (e |
| 23991634 | Our study shows that protein but not mRNA levels of CREB are reduced in the lungs of old mice |
| 23991634 | CREB reduction was also observed in senescent human lung fibroblasts (WI-38, LuFi) and human lung epithelial cells (A549) cultured on AGE-modified collagen matrix |
| 23991634 | Reduction of CREB protein is partially based on pre- and posttranslational modifications as exhibited by an increase in the CREB-regulating microRNA 34b and CREB ubiquitination |
| 23991634 | Permanent down-regulation of CREB in lung cells impaired cell proliferation and viability and increased the number of cells with senescence-associated beta-galactosidase activity |
| 23991634 | CREB down-regulation was accompanied by the reduced expression of 165 genes in WI-38 fibroblasts and A549 epithelial cells, of which 15 genes showed a reduced expression in lung tissues of old mice |
| 23991634 | Our data demonstrate that the reduced protein expression of CREB might play a significant role in lung aging by modifying the transcription of RAB27A, IGFBP3, and other target genes |
| 21047255 | By following this methodological approach, we recently obtained data fitting a model in which, in response to chronic impairment of cellular bioenergetics imposed by metformin-induced mitochondrial uncoupling as assessed by the phosphorylation state of cAMP-response element binding protein (CREB), tumor cells can retrogress from a differentiated state to a more CD44(+) stem-like primitive state epigenetically governed by the Polycomb-group suppressor BMI1-a crucial "stemness" gene involved in the epigenetic maintenance of adult stem cells |
| 20214903 | Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging |
| 20214903 | This work studied the role of cyclic AMP responsive element binding protein (CREB) in the up-regulation of M(1) muscarinic acetylcholine receptor (M(1) receptor) density by sarsasapogenin (ZMS) in CHO cells transfected with M(1) receptor gene (CHOm1 cells) |
| 20214903 | During cell aging, sarsasapogenin elevated M(1) receptor density as well as CREB and phosphor-CREB (pCREB) levels |
| 20214903 | CREB peaked earliest, followed by pCREB and M(1) receptor density peaked last |
| 20214903 | When CREB synthesis was blocked by antisense oligonucleotides, the elevation effect of sarsasapogenin on M(1) receptor density was abolished |
| 20214903 | These results suggest that sarsasapogenin up-regulates M(1) receptor density in aged cells by promoting CREB production and phosphorylation |
| 20193693 | Gi-protein inhibitor, guanosine 5'-O-(2-thiodiphosphate), induces senescence-associated beta-galactosidase positive cell formation through CREB phosphorylation |
| 20193693 | AIMS: We evaluated Gi-protein inhibitor, guanosine 5'-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-beta-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding protein (CREB) |
| 20193693 | CREB phosphorylation and molecular changes were analyzed by western blot |
| 20193693 | CREB phosphorylation increased in response to GOT treatment but then decreased over 24h |
| 20193693 | SA-beta-Gal positive cell formation increased in response to transient transfection of pS6-RSV-CREB and no changes were detected following CREB knockdown with CREB-siRNA |
| 20193693 | In addition, CREB phosphorylation was delayed by treatment with the anti-cellular senescence agents, clitocybins which also reduced the number of SA-beta-Gal positive cells |
| 20193693 | Collectively, our data showed that GOT-induced CREB phosphorylation initiated SA-beta-Gal positive cell formation after which decreased in SA-beta-Gal positive cells |
| 20193693 | SIGNIFICANCE: These findings suggest for the first time that CREB phosphorylation by GOT could induce cellular senescence as judged by SA-beta-Gal positive cell formation |
| 16672767 | In attempts to define the molecular events associated with the age-dependent changes in cAMP profiles, we determined the protein kinase A (PKA) activity, phosphorylation of cAMP-response element binding protein (CREB), and the protein expression of CRE-regulatory genes, c-fos and COX-2 in young and senescent HDFs |
| 16672767 | In young HDFs, CREB phosphorylation decreased following LPA treatment, and both c-fos and COX-2 protein levels increased rapidly |
| 16672767 | However, LPA-dependent slope of luciferase increased more rapidly in senescent cells than in young cells, presumably due to an increase of LPA-induced CREB phosphorylation |
| 8803927 | The promoter also contains sites for inducible transcription factors, cAMP-responsive element (CRE)-binding protein (CREB), and Activator protein 2 (AP-2) |
| 8760066 | The abundance of the cAMP response element binding protein (CREB), a transcription factor which enhances gene expression when phosphorylated by protein kinase A, was markedly decreased in both whole cell and nuclear extracts of senescent cells, in both Western blotting and in gel retardation assays |
| 8760066 | Also, PGE1-induced phosphorylation of CREB by protein kinase A was markedly attenuated in senescent cells |
| 8760066 | There is a marked decrement in expression of CREB with senescence, and the results suggest the possibility that the diminished expression of CREB may contribute to altered cAMP-mediated regulation of gene expression with senescence |
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