HCSGD entry for CPE
1. General information
| Official gene symbol | CPE |
|---|---|
| Entrez ID | 1363 |
| Gene full name | carboxypeptidase E |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003214 | Cardiac left ventricle morphogenesis | IMP | biological_process |
| GO:0004180 | Carboxypeptidase activity | TAS | molecular_function |
| GO:0004181 | Metallocarboxypeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007218 | Neuropeptide signaling pathway | NAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0030070 | Insulin processing | IEA | biological_process |
| GO:0030658 | Transport vesicle membrane | IEA | cellular_component |
| GO:0030667 | Secretory granule membrane | TAS | cellular_component |
| GO:0042043 | Neurexin family protein binding | IPI | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IPI | molecular_function |
| GO:0072657 | Protein localization to membrane | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0150414004 | 0.0090630219 | 0.3047552308 | 0.1885753360 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6780543987 |
| GSE13712_SHEAR | Down | -4.0492766076 |
| GSE13712_STATIC | Down | -2.1128813615 |
| GSE19018 | Down | -3.2594214670 |
| GSE19899_A1 | Up | 0.3890346629 |
| GSE19899_A2 | Up | 0.3561614409 |
| PubMed_21979375_A1 | Down | -0.0936529772 |
| PubMed_21979375_A2 | Up | 0.0637722914 |
| GSE35957 | Up | 2.4854680324 |
| GSE36640 | Up | 0.5257516258 |
| GSE54402 | Down | -0.4952495851 |
| GSE9593 | Up | 0.0081430040 |
| GSE43922 | Up | 0.2373433496 |
| GSE24585 | Down | -0.0568320688 |
| GSE37065 | Down | -0.0482449088 |
| GSE28863_A1 | Up | 0.4219273158 |
| GSE28863_A2 | Up | 1.6658546881 |
| GSE28863_A3 | Up | 0.9260819236 |
| GSE28863_A4 | Down | -0.3836559946 |
| GSE48662 | Up | 0.5921886542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Insulin Pork | DB00071 | BTD00031 | BIOD00031 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018916 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050834 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20040591 | Although the CPE does not regulate mRNA export, it influences the degree to which mRNAs are translationally repressed in the cytoplasm |
| 17481902 | This cytoplasmic polyadenylation element (CPE) is the binding platform for CPE-binding protein (CPEB), which promotes polyadenylation-induced translation |
| 2459727 | In order to compare the conventional reading method of cytopathic effect (CPE) with the staining technique of cell monolayers with crystal violet-formol, the reference viruses and several lots of trivalent vaccines were titrated |
| 2459727 | The maximum viral titer was reached at 5-7 days pi and additional CPE after this period did not alter the results |
| 2459727 | By contrast, CPE was easily read by microscope observation |
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