HCSGD entry for CPD
1. General information
| Official gene symbol | CPD |
|---|---|
| Entrez ID | 1362 |
| Gene full name | carboxypeptidase D |
| Other gene symbols | GP180 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004181 | Metallocarboxypeptidase activity | IEA | molecular_function |
| GO:0004185 | Serine-type carboxypeptidase activity | IEA | molecular_function |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2500862353 | 0.0991137381 | 0.9394205509 | 0.6027663355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2641892254 |
| GSE13712_SHEAR | Down | -0.4291248544 |
| GSE13712_STATIC | Down | -0.3776543749 |
| GSE19018 | Up | 0.3982604757 |
| GSE19899_A1 | Down | -0.4304503051 |
| GSE19899_A2 | Down | -0.3393497245 |
| PubMed_21979375_A1 | Down | -0.7312493457 |
| PubMed_21979375_A2 | Down | -0.1126876945 |
| GSE35957 | Up | 0.4395006641 |
| GSE36640 | Up | 0.6133830269 |
| GSE54402 | Down | -0.2901350658 |
| GSE9593 | Up | 0.5015856713 |
| GSE43922 | Down | -0.3202310364 |
| GSE24585 | Up | 0.1795855964 |
| GSE37065 | Down | -0.0836275936 |
| GSE28863_A1 | Up | 0.9486092381 |
| GSE28863_A2 | Up | 0.9619089396 |
| GSE28863_A3 | Down | -0.3623811697 |
| GSE28863_A4 | Down | -0.0443306402 |
| GSE48662 | Down | -0.2481972004 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanidinoethylmercaptosuccinic acid | DB04489 | EXPT01581 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020910 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026089 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031284 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320a | MIMAT0000510 | MIRT044809 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24878779 | The results obtained were confronted with the cumulative number of population doublings (CPD) and the calendar age of the tissue donor |
| 24878779 | Cytochemical SA-beta-Gal staining in early-passage cultures negatively correlated with CPD values but not with donor age in both cell cultures and omentum specimens |
| 24878779 | At the same time it was not related to the CPD values |
| 20816692 | In the present report we compare age-related metabolic and synthetic parameters in human dermal fibroblasts (HDF) isolated from young and old subjects (ex vivo ageing model) and cultured from early up to late cumulative population doublings (CPD) (in vitro ageing model) in order to distinguish changes induced in vivo by the aged environment and maintained in vitro, from those associated with cell senescence and progressive CPD |
| 20816692 | In the present report we compare age-related metabolic and synthetic parameters in human dermal fibroblasts (HDF) isolated from young and old subjects (ex vivo ageing model) and cultured from early up to late cumulative population doublings (CPD) (in vitro ageing model) in order to distinguish changes induced in vivo by the aged environment and maintained in vitro, from those associated with cell senescence and progressive CPD |
| 20816692 | Results demonstrate that fibroblasts from aged donors, already at early CPD, exhibit an impaired redox balance, highlighting the importance of this parameter during ageing, even in the presence of standard environmental conditions, which are considered optimal for cell growth |
| 20816692 | By contrast, several proteins, as those related to heat shock response, or involved in endoplasmic reticulum and membrane trafficking, appeared differentially expressed only during in vitro ageing, suggesting that, at high CPD, the whole cell machinery becomes permanently altered |
| 9402476 | Southern blot analysis revealed that the copy number and the methylation state of the genes did not change significantly with increasing cumulative population doublings (CPD) of the culture |
| 9402476 | Hence, young (low numbers of CPD) and senescent REF (high numbers of CPD), respectively, have the same repertoire of rDNA units that can be transcribed |
| 9402476 | Hence, young (low numbers of CPD) and senescent REF (high numbers of CPD), respectively, have the same repertoire of rDNA units that can be transcribed |
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