HCSGD entry for ADORA2A

1. General information

Official gene symbol	ADORA2A
Entrez ID	135
Gene full name	adenosine A2a receptor
Other gene symbols	ADORA2 RDC8 hA2aR
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001609	G-protein coupled adenosine receptor activity	IDA IEA	molecular_function
GO:0001963	Synaptic transmission, dopaminergic	IEA	biological_process
GO:0001975	Response to amphetamine	IEA	biological_process
GO:0005515	Protein binding	IPI	molecular_function
GO:0005886	Plasma membrane	IDA TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IMP	cellular_component
GO:0006171	CAMP biosynthetic process	TAS	biological_process
GO:0006355	Regulation of transcription, DNA-templated	IEA	biological_process
GO:0006469	Negative regulation of protein kinase activity	IEA	biological_process
GO:0006909	Phagocytosis	TAS	biological_process
GO:0006915	Apoptotic process	TAS	biological_process
GO:0006954	Inflammatory response	TAS	biological_process
GO:0006968	Cellular defense response	TAS	biological_process
GO:0007169	Transmembrane receptor protein tyrosine kinase signaling pathway	TAS	biological_process
GO:0007188	Adenylate cyclase-modulating G-protein coupled receptor signaling pathway	TAS	biological_process
GO:0007189	Adenylate cyclase-activating G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0007190	Activation of adenylate cyclase activity	TAS	biological_process
GO:0007205	Protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0007267	Cell-cell signaling	TAS	biological_process
GO:0007271	Synaptic transmission, cholinergic	IEA	biological_process
GO:0007417	Central nervous system development	TAS	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0007600	Sensory perception	TAS	biological_process
GO:0007626	Locomotory behavior	IEA	biological_process
GO:0008015	Blood circulation	TAS	biological_process
GO:0008285	Negative regulation of cell proliferation	IEA	biological_process
GO:0010579	Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	IDA	biological_process
GO:0012505	Endomembrane system	IEA	cellular_component
GO:0014049	Positive regulation of glutamate secretion	IEA	biological_process
GO:0014057	Positive regulation of acetylcholine secretion, neurotransmission	IEA	biological_process
GO:0014061	Regulation of norepinephrine secretion	IEA	biological_process
GO:0014069	Postsynaptic density	IEA	cellular_component
GO:0016020	Membrane	TAS	cellular_component
GO:0016021	Integral component of membrane	IEA	cellular_component
GO:0019899	Enzyme binding	IPI	molecular_function
GO:0030425	Dendrite	IEA	cellular_component
GO:0030673	Axolemma	IEA	cellular_component
GO:0030819	Positive regulation of cAMP biosynthetic process	IEA	biological_process
GO:0031000	Response to caffeine	IEA	biological_process
GO:0031802	Type 5 metabotropic glutamate receptor binding	IEA	molecular_function
GO:0032230	Positive regulation of synaptic transmission, GABAergic	IEA	biological_process
GO:0032279	Asymmetric synapse	IEA	cellular_component
GO:0035249	Synaptic transmission, glutamatergic	IEA	biological_process
GO:0035810	Positive regulation of urine volume	IEA	biological_process
GO:0035815	Positive regulation of renal sodium excretion	IEA	biological_process
GO:0040013	Negative regulation of locomotion	IEA	biological_process
GO:0042311	Vasodilation	IEA	biological_process
GO:0042493	Response to drug	IEA	biological_process
GO:0042734	Presynaptic membrane	IEA	cellular_component
GO:0042755	Eating behavior	IEA	biological_process
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0043025	Neuronal cell body	IEA	cellular_component
GO:0043116	Negative regulation of vascular permeability	IEA	biological_process
GO:0043154	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological_process
GO:0043524	Negative regulation of neuron apoptotic process	IEA	biological_process
GO:0045211	Postsynaptic membrane	IEA	cellular_component
GO:0045938	Positive regulation of circadian sleep/wake cycle, sleep	IEA	biological_process
GO:0046636	Negative regulation of alpha-beta T cell activation	IEA	biological_process
GO:0046982	Protein heterodimerization activity	IEA	molecular_function
GO:0048011	Neurotrophin TRK receptor signaling pathway	TAS	biological_process
GO:0048143	Astrocyte activation	IEA	biological_process
GO:0048167	Regulation of synaptic plasticity	IEA	biological_process
GO:0048786	Presynaptic active zone	IEA	cellular_component
GO:0048812	Neuron projection morphogenesis	IEA	biological_process
GO:0050714	Positive regulation of protein secretion	IEA	biological_process
GO:0050728	Negative regulation of inflammatory response	IEA	biological_process
GO:0051393	Alpha-actinin binding	IEA	molecular_function
GO:0051881	Regulation of mitochondrial membrane potential	IEA	biological_process
GO:0051924	Regulation of calcium ion transport	IEA	biological_process
GO:0051968	Positive regulation of synaptic transmission, glutamatergic	IEA	biological_process
GO:0060079	Regulation of excitatory postsynaptic membrane potential	IEA	biological_process
GO:0060080	Regulation of inhibitory postsynaptic membrane potential	IEA	biological_process
GO:0060134	Prepulse inhibition	IEA	biological_process
GO:2001235	Positive regulation of apoptotic signaling pathway	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.9393850120	0.7367764219	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	-	-
GSE13712_SHEAR	-	-
GSE13712_STATIC	-	-
GSE19018	-	-
GSE19899_A1	-	-
GSE19899_A2	-	-
PubMed_21979375_A1	-	-
PubMed_21979375_A2	-	-
GSE35957	-	-
GSE36640	-	-
GSE54402	-	-
GSE9593	-	-
GSE43922	-	-
GSE24585	-	-
GSE37065	-	-
GSE28863_A1	Down	-0.1298727132
GSE28863_A2	Down	-0.2541538478
GSE28863_A3	Up	0.1681165083
GSE28863_A4	Up	0.1116630433
GSE48662	Down	-0.0116504355

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Theophylline	DB00277	APRD00082 \| DB09359
Mefloquine	DB00358	APRD00300
Pentoxifylline	DB00806	APRD00121
Enprofylline	DB00824	APRD00273
Oxtriphylline	DB01303	-
Theobromine	DB01412	-
Binodenoson	DB04853	-
Defibrotide	DB04932	-
Apadenoson	DB05009	-
Atl146e	DB05191	-
Regadenoson	DB06213	-
4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol	DB08770	-

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for ADORA2A

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )