HCSGD entry for PPARGC1B
1. General information
| Official gene symbol | PPARGC1B |
|---|---|
| Entrez ID | 133522 |
| Gene full name | peroxisome proliferator-activated receptor gamma, coactivator 1 beta |
| Other gene symbols | ERRL1 PERC PGC-1(beta) PGC1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA | molecular_function |
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006390 | Transcription from mitochondrial promoter | IEA | biological_process |
| GO:0007015 | Actin filament organization | IEA | biological_process |
| GO:0010469 | Regulation of receptor activity | IDA | biological_process |
| GO:0010694 | Positive regulation of alkaline phosphatase activity | IEA | biological_process |
| GO:0016592 | Mediator complex | IDA | cellular_component |
| GO:0030331 | Estrogen receptor binding | IDA | molecular_function |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IDA | molecular_function |
| GO:0030520 | Intracellular estrogen receptor signaling pathway | IDA | biological_process |
| GO:0030546 | Receptor activator activity | IDA | molecular_function |
| GO:0034614 | Cellular response to reactive oxygen species | IEA | biological_process |
| GO:0042327 | Positive regulation of phosphorylation | IEA | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045672 | Positive regulation of osteoclast differentiation | IEA | biological_process |
| GO:0045780 | Positive regulation of bone resorption | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0050682 | AF-2 domain binding | IPI | molecular_function |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
| GO:0060346 | Bone trabecula formation | IEA | biological_process |
| GO:2000273 | Positive regulation of receptor activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0453241708 | 0.9661888530 | 0.4730283505 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0149681981 |
| GSE13712_SHEAR | Up | 0.0536523771 |
| GSE13712_STATIC | Up | 0.2780752404 |
| GSE19018 | Up | 0.0654448720 |
| GSE19899_A1 | Up | 0.3517635969 |
| GSE19899_A2 | Up | 0.8262913465 |
| PubMed_21979375_A1 | Up | 0.6492991343 |
| PubMed_21979375_A2 | Up | 0.9882465953 |
| GSE35957 | Up | 0.0601066720 |
| GSE36640 | Up | 0.0124123754 |
| GSE54402 | Up | 0.4810070666 |
| GSE9593 | Down | -0.2128116474 |
| GSE43922 | Up | 0.0880351758 |
| GSE24585 | Down | -0.3112702345 |
| GSE37065 | Down | -0.1292689283 |
| GSE28863_A1 | Up | 0.1018370661 |
| GSE28863_A2 | Up | 0.1827893346 |
| GSE28863_A3 | Up | 0.3743901851 |
| GSE28863_A4 | Up | 0.2201710105 |
| GSE48662 | Down | -0.0054179224 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-423-5p | MIMAT0004748 | MIRT038154 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041586 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042182 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044931 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046313 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3687 | MIMAT0018115 | MIRT052880 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26848154 | Finally, we demonstrate that the reduction in mitochondrial content in vivo, by either mTORC1 inhibition or PGC-1beta deletion, prevents senescence in the ageing mouse liver |
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