HCSGD entry for ADM

1. General information

Official gene symbolADM
Entrez ID133
Gene full nameadrenomedullin
Other gene symbolsAM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001570VasculogenesisIDAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0002026Regulation of the force of heart contractionIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006171CAMP biosynthetic processIDAbiological_process
GO:0006701Progesterone biosynthetic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008209Androgen metabolic processIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0010460Positive regulation of heart rateIEAbiological_process
GO:0019933CAMP-mediated signalingIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031102Neuron projection regenerationIEAbiological_process
GO:0031623Receptor internalizationIDAbiological_process
GO:0031700Adrenomedullin receptor bindingIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043116Negative regulation of vascular permeabilityIEAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0045906Negative regulation of vasoconstrictionIDAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0046879Hormone secretionIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060670Branching involved in labyrinthine layer morphogenesisIEAbiological_process
GO:0060712Spongiotrophoblast layer developmentIEAbiological_process
GO:0097084Vascular smooth muscle cell developmentIEAbiological_process
GO:2001214Positive regulation of vasculogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05525555640.13106691240.51178832220.6971158384

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4373006856
GSE13712_SHEARDown-0.5229039234
GSE13712_STATICDown-0.3520268740
GSE19018Up0.6459923780
GSE19899_A1Down-0.4037239344
GSE19899_A2Up0.4748302261
PubMed_21979375_A1Up0.7693068599
PubMed_21979375_A2Up0.1432362476
GSE35957Up1.1881037057
GSE36640Down-0.2778777996
GSE54402Down-0.4272212749
GSE9593Up1.1607309215
GSE43922Down-0.1962530897
GSE24585Down-0.0742890433
GSE37065Up0.1482009259
GSE28863_A1Up0.2445981051
GSE28863_A2Down-0.0049710922
GSE28863_A3Up0.1869935627
GSE28863_A4Down-0.0058385218
GSE48662Up0.4348423634

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029565SequencingFunctional MTI (Weak)20371350
hsa-miR-125b-5pMIMAT0000423MIRT045894CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050138CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23551866Expression of adrenomedullin (ADM), heat shock 70 kDa protein 8 (HSPA8) and prostaglandin E synthase (PGES) in OPEC was measured by quantitative polymerase chain reaction
23551866The expression of ADM and HSPA8 was decreased significantly in OPEC cells from Passage 57, particularly in the later subculture group
23551866These effects on HSPA8, but not ADM, expression in OPEC were further altered after coculture with spermatozoa for 24 h
23551866We also demonstrated that spermatozoa-oviduct coculture for 12 and 24 h resulted in significantly higher expression of ADM, HSPA8 and PGES in OPEC
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