HCSGD entry for CPEB2
1. General information
| Official gene symbol | CPEB2 |
|---|---|
| Entrez ID | 132864 |
| Gene full name | cytoplasmic polyadenylation element binding protein 2 |
| Other gene symbols | CPE-BP2 CPEB-2 hCPEB-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000900 | Translation repressor activity, nucleic acid binding | ISS | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005095 | GTPase inhibitor activity | ISS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005844 | Polysome | IEA | cellular_component |
| GO:0008187 | Poly-pyrimidine tract binding | IEA | molecular_function |
| GO:0032869 | Cellular response to insulin stimulus | IDA | biological_process |
| GO:0033125 | Negative regulation of GTP catabolic process | IEA | biological_process |
| GO:0034260 | Negative regulation of GTPase activity | ISS | biological_process |
| GO:0034599 | Cellular response to oxidative stress | ISS | biological_process |
| GO:0035925 | MRNA 3'-UTR AU-rich region binding | ISS | molecular_function |
| GO:0043022 | Ribosome binding | ISS | molecular_function |
| GO:0043023 | Ribosomal large subunit binding | ISS | molecular_function |
| GO:0043024 | Ribosomal small subunit binding | ISS | molecular_function |
| GO:0045900 | Negative regulation of translational elongation | IEA | biological_process |
| GO:0071243 | Cellular response to arsenic-containing substance | ISS | biological_process |
| GO:0071456 | Cellular response to hypoxia | IDA | biological_process |
| GO:1900248 | Negative regulation of cytoplasmic translational elongation | ISS | biological_process |
| GO:1990124 | Messenger ribonucleoprotein complex | ISS | cellular_component |
| GO:2000766 | Negative regulation of cytoplasmic translation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3606155579 | 0.0630547168 | 0.9999902473 | 0.4736866515 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5373496365 |
| GSE13712_SHEAR | Up | 0.2288903258 |
| GSE13712_STATIC | Up | 0.1712930012 |
| GSE19018 | Down | -0.3714154990 |
| GSE19899_A1 | Up | 0.4468940054 |
| GSE19899_A2 | Up | 0.4204737039 |
| PubMed_21979375_A1 | Down | -0.1494467642 |
| PubMed_21979375_A2 | Up | 0.3275414972 |
| GSE35957 | Down | -0.1181053370 |
| GSE36640 | Up | 1.0392919088 |
| GSE54402 | Down | -0.9682473779 |
| GSE9593 | Up | 0.4959488290 |
| GSE43922 | Down | -0.3645295239 |
| GSE24585 | Down | -0.7596562567 |
| GSE37065 | Up | 0.3716456384 |
| GSE28863_A1 | Down | -0.1017409994 |
| GSE28863_A2 | Up | 0.0412927439 |
| GSE28863_A3 | Down | -0.2574890123 |
| GSE28863_A4 | Down | -0.2210699941 |
| GSE48662 | Down | -0.4427501870 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003167 | immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 19826008 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT005587 | Luciferase reporter assay//Northern blot//qRT-PCR | Functional MTI | 20660482 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT005590 | Luciferase reporter assay//Northern blot//qRT-PCR | Functional MTI | 20660482 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017639 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027130 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25483308 | Aside from a brief description of CPEB2 in mouse brain, not much is known about its biological role |
| 25483308 | Hence, this study aims to investigate CPEB2 expression in mouse brain |
| 25483308 | With reverse transcription polymerase chain reaction (RT-PCR) of total mouse brain cDNA, we identified four distinct CPEB2 splice variants |
| 25483308 | Single-cell RT-PCR showed that CPEB2 is predominantly expressed in neurons of the juvenile and adult brain and that individual cells express different sets of splice variants |
| 25483308 | Staining of brain slices with a custom-made CPEB2 antibody revealed ubiquitous expression of the protein in many brain regions, including hippocampus, striatum, thalamus, cortex, and cerebellum |
| 25483308 | We also found differential expression of CPEB2 protein in excitatory, inhibitory, and dopaminergic neurons |
| 25483308 | In primary hippocampal cultures, the subcellular localization of CPEB2 in neurons and astrocytes resembled that of CPEB1 |
| 25483308 | Electrophoretic mobility shift assay and RNA coimmunoprecipitation revealed CPEB2 interaction with beta-catenin and Ca(2+) /calmodulin-dependent protein kinase II (both established CPEB1 targets), indicating an overlap in RNA binding specificity between CPEB1 and CPEB2 |
| 25483308 | Furthermore, we identified ephrin receptor A4 as a putative novel target of CPEB2 |
| 25483308 | In conclusion, our study identifies CPEB2 splice variants to be differentially expressed among individual cells and across cell types of the mouse hippocampus, and reveals overlapping binding specificity between CPEB2 and CPEB1 |
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