HCSGD entry for COX4I1
1. General information
| Official gene symbol | COX4I1 |
|---|---|
| Entrez ID | 1327 |
| Gene full name | cytochrome c oxidase subunit IV isoform 1 |
| Other gene symbols | COX4 COX4-1 COXIV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004129 | Cytochrome-c oxidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA TAS | cellular_component |
| GO:0006091 | Generation of precursor metabolites and energy | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006812 | Cation transport | TAS | biological_process |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0015672 | Monovalent inorganic cation transport | TAS | biological_process |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:1902600 | Hydrogen ion transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3466571711 | 0.8725701341 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2051374779 |
| GSE13712_SHEAR | Down | -0.0219820583 |
| GSE13712_STATIC | Down | -0.1995622130 |
| GSE19018 | Up | 0.2544989980 |
| GSE19899_A1 | Down | -0.0695836993 |
| GSE19899_A2 | Up | 0.1527965304 |
| PubMed_21979375_A1 | Down | -0.0707954237 |
| PubMed_21979375_A2 | Down | -0.0242866724 |
| GSE35957 | Up | 0.0857447065 |
| GSE36640 | Up | 0.4908152163 |
| GSE54402 | Up | 0.2286446296 |
| GSE9593 | Down | -0.1018164925 |
| GSE43922 | Down | -0.0008877790 |
| GSE24585 | Down | -0.2251034505 |
| GSE37065 | Up | 0.0261087614 |
| GSE28863_A1 | Up | 0.2053439342 |
| GSE28863_A2 | Down | -0.1367728503 |
| GSE28863_A3 | Up | 0.4207365705 |
| GSE28863_A4 | Up | 0.0832833397 |
| GSE48662 | Down | -0.0000144867 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049222 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22987635 | We show that the mitochondrial complex IV subunit cytochrome C oxidase subunit 4 (Cox4i1) is a direct TAp73 target and that Cox4i1 knockdown phenocopies the cellular senescence of TAp73-null cells |
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