HCSGD entry for MAP3K8
1. General information
| Official gene symbol | MAP3K8 |
|---|---|
| Entrez ID | 1326 |
| Gene full name | mitogen-activated protein kinase kinase kinase 8 |
| Other gene symbols | COT EST ESTF MEKK8 TPL2 Tpl-2 c-COT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IBA | biological_process |
| GO:0000186 | Activation of MAPKK activity | IBA | biological_process |
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0038658752 | 0.2329535048 | 0.1672442623 | 0.9298734759 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.3152125385 |
| GSE13712_SHEAR | Down | -0.7559346758 |
| GSE13712_STATIC | Down | -0.3863006595 |
| GSE19018 | Down | -0.0986193157 |
| GSE19899_A1 | Up | 0.2634672795 |
| GSE19899_A2 | Up | 1.2273411976 |
| PubMed_21979375_A1 | Up | 2.8097271241 |
| PubMed_21979375_A2 | Up | 1.7451370503 |
| GSE35957 | Up | 0.9637356355 |
| GSE36640 | Down | -0.6994493927 |
| GSE54402 | Up | 0.1895251114 |
| GSE9593 | Up | 0.2988165424 |
| GSE43922 | Up | 0.5360662939 |
| GSE24585 | Up | 1.7530420882 |
| GSE37065 | Up | 0.6027978964 |
| GSE28863_A1 | Up | 0.3106106672 |
| GSE28863_A2 | Up | 0.4967479359 |
| GSE28863_A3 | Down | -0.3003079099 |
| GSE28863_A4 | Up | 0.0519256931 |
| GSE48662 | Down | -0.5358736594 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-370-3p | MIMAT0000722 | MIRT001074 | Luciferase reporter assay//Western blot | Functional MTI | 17621267 |
| hsa-miR-375 | MIMAT0000728 | MIRT007200 | Luciferase reporter assay | Functional MTI | 23430746 |
| hsa-miR-374b-5p | MIMAT0004955 | MIRT016056 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017102 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022367 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051038 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
