HCSGD entry for COMT

1. General information

Official gene symbolCOMT
Entrez ID1312
Gene full namecatechol-O-methyltransferase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006584Catecholamine metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007612LearningIEAbiological_process
GO:0008171O-methyltransferase activityIEA TASmolecular_function
GO:0008210Estrogen metabolic processIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016206Catechol O-methyltransferase activityIEAmolecular_function
GO:0032259MethylationTASbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0042135Neurotransmitter catabolic processIEAbiological_process
GO:0042136Neurotransmitter biosynthetic processTASbiological_process
GO:0042420Dopamine catabolic processIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045963Negative regulation of dopamine metabolic processIEAbiological_process
GO:0048265Response to painIEAbiological_process
GO:0048609Multicellular organismal reproductive processIEAbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050668Positive regulation of homocysteine metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42229532690.30511613920.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0695440185
GSE13712_SHEARDown-0.0090970185
GSE13712_STATICDown-0.0343498093
GSE19018Up0.1855926334
GSE19899_A1Down-0.3379973559
GSE19899_A2Up0.3828637791
PubMed_21979375_A1Up0.2340056625
PubMed_21979375_A2Up0.0120743181
GSE35957Up0.0776351587
GSE36640Up0.7228900652
GSE54402Down-0.2938177811
GSE9593Up0.4383981652
GSE43922Down-0.0740308478
GSE24585Down-0.2163222989
GSE37065Down-0.1096573829
GSE28863_A1Up0.1016108999
GSE28863_A2Down-0.1566894104
GSE28863_A3Down-0.1607646307
GSE28863_A4Down-0.2585102149
GSE48662Up0.6009567684

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TolcaponeDB00323 APRD00445
EntacaponeDB00494 APRD00416
3,5-DinitrocatecholDB02105 EXPT01233
2-MethoxyestradiolDB02342 EXPT01362
BIADB03336 EXPT00705
N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-BenzamideDB03907 EXPT00934
(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONEDB07462 -
7,8-dihydroxy-4-phenyl-2H-chromen-2-oneDB08049 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031679ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031679CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.