HCSGD entry for COMP
1. General information
| Official gene symbol | COMP |
|---|---|
| Entrez ID | 1311 |
| Gene full name | cartilage oligomeric matrix protein |
| Other gene symbols | EDM1 EPD1 MED PSACH THBS5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0003417 | Growth plate cartilage development | IEA | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043395 | Heparan sulfate proteoglycan binding | IDA | molecular_function |
| GO:0060173 | Limb development | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1326273774 | 0.0436659169 | 0.7377187658 | 0.3930763338 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1617301210 |
| GSE13712_SHEAR | Down | -0.0155639025 |
| GSE13712_STATIC | Up | 0.0770663024 |
| GSE19018 | Up | 0.3515465975 |
| GSE19899_A1 | Down | -0.1159339555 |
| GSE19899_A2 | Down | -0.2210235261 |
| PubMed_21979375_A1 | Down | -0.0083370841 |
| PubMed_21979375_A2 | Up | 0.0947730159 |
| GSE35957 | Up | 2.1496836333 |
| GSE36640 | Up | 0.3641433904 |
| GSE54402 | Down | -0.0570066169 |
| GSE9593 | Down | -0.7673829758 |
| GSE43922 | Up | 0.1525518621 |
| GSE24585 | Up | 0.1452727388 |
| GSE37065 | Down | -0.9283160094 |
| GSE28863_A1 | Up | 0.0098451612 |
| GSE28863_A2 | Down | -0.3593111229 |
| GSE28863_A3 | Down | -0.9865788284 |
| GSE28863_A4 | Down | -0.5887722252 |
| GSE48662 | Up | 1.4044513365 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Calcium | DB01373 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Genes specifically up-regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor (Timp1), transgelin (Tagln), gamma 2 actin (Actg2), plasminogen activator inhibitor 1 (Serpinel), insulin-like growth factor binding protein 3 (Igfbp3), parathyroid hormone-like hormone (Pthlp), Tgfb-1, four and a half LIM domains 2 (Fhl-2), hydrogen peroxide-inducible clone 5 (Hic5) and cartilage oligomeric matrix protein (Comp) |
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