HCSGD entry for IQGAP3
1. General information
| Official gene symbol | IQGAP3 |
|---|---|
| Entrez ID | 128239 |
| Gene full name | IQ motif containing GTPase activating protein 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0000187 | Activation of MAPK activity | IEA | biological_process |
| GO:0005099 | Ras GTPase activator activity | IEA | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | IEA | cellular_component |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0008361 | Regulation of cell size | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0033601 | Positive regulation of mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0070371 | ERK1 and ERK2 cascade | IEA | biological_process |
| GO:0071310 | Cellular response to organic substance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9131827476 | 0.0014872991 | 0.9999902473 | 0.0751078394 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4924756955 |
| GSE13712_SHEAR | Down | -0.0252824774 |
| GSE13712_STATIC | Down | -0.3513699753 |
| GSE19018 | Up | 0.4779137568 |
| GSE19899_A1 | Down | -0.4523351342 |
| GSE19899_A2 | Down | -0.9477653875 |
| PubMed_21979375_A1 | Down | -1.5574028066 |
| PubMed_21979375_A2 | Down | -1.1977062741 |
| GSE35957 | Down | -0.6704271348 |
| GSE36640 | Down | -3.5207476041 |
| GSE54402 | Down | -1.2470165451 |
| GSE9593 | Down | -0.4695617395 |
| GSE43922 | Down | -0.7988654913 |
| GSE24585 | Down | -0.0147404524 |
| GSE37065 | Down | -0.5937561064 |
| GSE28863_A1 | Up | 0.0736583377 |
| GSE28863_A2 | Up | 0.6261714982 |
| GSE28863_A3 | Up | 0.2713417454 |
| GSE28863_A4 | Up | 0.0783538972 |
| GSE48662 | Down | -1.1303151781 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001363 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
