HCSGD entry for COL4A1
1. General information
| Official gene symbol | COL4A1 |
|---|---|
| Entrez ID | 1282 |
| Gene full name | collagen, type IV, alpha 1 |
| Other gene symbols | HANAC ICH POREN1 arresten |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005587 | Collagen type IV | IEA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007528 | Neuromuscular junction development | IEA | biological_process |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0030855 | Epithelial cell differentiation | IEA | biological_process |
| GO:0031012 | Extracellular matrix | ISS | cellular_component |
| GO:0048407 | Platelet-derived growth factor binding | IDA | molecular_function |
| GO:0071230 | Cellular response to amino acid stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6643398427 | 0.0002616010 | 0.9999902473 | 0.0291762712 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.0391121140 |
| GSE13712_SHEAR | Down | -0.0468405606 |
| GSE13712_STATIC | Down | -0.1302181299 |
| GSE19018 | Up | 0.4517546009 |
| GSE19899_A1 | Down | -1.6033373412 |
| GSE19899_A2 | Down | -2.0107914488 |
| PubMed_21979375_A1 | Down | -2.7978369474 |
| PubMed_21979375_A2 | Down | -2.4529345980 |
| GSE35957 | Up | 0.2942973366 |
| GSE36640 | Up | 0.4404357456 |
| GSE54402 | Down | -2.6542745703 |
| GSE9593 | Down | -0.3491167507 |
| GSE43922 | Down | -0.4218601820 |
| GSE24585 | Down | -0.6077236421 |
| GSE37065 | Down | -0.4653085817 |
| GSE28863_A1 | Down | -0.0399533232 |
| GSE28863_A2 | Down | -0.2958934928 |
| GSE28863_A3 | Up | 0.4757991312 |
| GSE28863_A4 | Up | 0.1490190057 |
| GSE48662 | Down | -0.2189516428 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001927 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18390668 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001927 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003221 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20067797 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005568 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20657750 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022172 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT024242 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040877 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041389 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045748 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048584 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048676 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049483 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051073 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
