HCSGD entry for CCR4
1. General information
| Official gene symbol | CCR4 |
|---|---|
| Entrez ID | 1233 |
| Gene full name | chemokine (C-C motif) receptor 4 |
| Other gene symbols | CC-CKR-4 CD194 CKR4 CMKBR4 ChemR13 HGCN:14099 K5-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0002507 | Tolerance induction | IEA | biological_process |
| GO:0004950 | Chemokine receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006935 | Chemotaxis | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0009314 | Response to radiation | IEA | biological_process |
| GO:0009617 | Response to bacterium | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016493 | C-C chemokine receptor activity | IEA | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0046677 | Response to antibiotic | IEA | biological_process |
| GO:0050927 | Positive regulation of positive chemotaxis | IEA | biological_process |
| GO:0070098 | Chemokine-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3849425174 | 0.8760004977 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0699218796 |
| GSE13712_SHEAR | Up | 0.0114196332 |
| GSE13712_STATIC | Up | 0.1977871698 |
| GSE19018 | Up | 0.2580746308 |
| GSE19899_A1 | Up | 0.1841506834 |
| GSE19899_A2 | Down | 0.0000000000 |
| PubMed_21979375_A1 | Down | -0.1549434315 |
| PubMed_21979375_A2 | Down | -0.1392241858 |
| GSE35957 | Up | 0.1600838058 |
| GSE36640 | Up | 0.0191209149 |
| GSE54402 | Down | -0.1632727181 |
| GSE9593 | Down | -0.1262331129 |
| GSE43922 | Up | 0.0147971806 |
| GSE24585 | Up | 0.7810879244 |
| GSE37065 | Down | -0.0280302949 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0161099474 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018019 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16821141 | In inflamed portal tracts of PBC, CD4+ T cells of Th1 type expressing IFN-gamma or CXCR3 are aggregated and more commonly detected around injured bile ducts than Th2-type CD4+ T cells expressing IL-4 or CCR4, indicating that Th1-dominant cellular immunity plays a more-prominent role in recruitment of memory T-cell subsets in PBC and may be responsible for the progressive bile duct damage |
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