HCSGD entry for CLN3
1. General information
| Official gene symbol | CLN3 |
|---|---|
| Entrez ID | 1201 |
| Gene full name | ceroid-lipofuscinosis, neuronal 3 |
| Other gene symbols | BTS JNCL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000046 | Autophagic vacuole fusion | ISS | biological_process |
| GO:0000139 | Golgi membrane | IDA | cellular_component |
| GO:0001508 | Action potential | ISS | biological_process |
| GO:0001575 | Globoside metabolic process | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA IEA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA ISS | cellular_component |
| GO:0005776 | Autophagic vacuole | ISS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005795 | Golgi stack | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006520 | Cellular amino acid metabolic process | ISS | biological_process |
| GO:0006672 | Ceramide metabolic process | IDA | biological_process |
| GO:0006678 | Glucosylceramide metabolic process | IMP | biological_process |
| GO:0006681 | Galactosylceramide metabolic process | IMP | biological_process |
| GO:0006684 | Sphingomyelin metabolic process | IMP | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | IMP | biological_process |
| GO:0007034 | Vacuolar transport | IBA | biological_process |
| GO:0007040 | Lysosome organization | ISS | biological_process |
| GO:0007042 | Lysosomal lumen acidification | IMP | biological_process |
| GO:0008021 | Synaptic vesicle | IDA | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008306 | Associative learning | ISS | biological_process |
| GO:0015809 | Arginine transport | IDA | biological_process |
| GO:0016021 | Integral component of membrane | IDA IEA | cellular_component |
| GO:0016236 | Macroautophagy | NAS | biological_process |
| GO:0016242 | Negative regulation of macroautophagy | ISS | biological_process |
| GO:0016485 | Protein processing | ISS | biological_process |
| GO:0030163 | Protein catabolic process | NAS | biological_process |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0035235 | Ionotropic glutamate receptor signaling pathway | ISS | biological_process |
| GO:0035752 | Lysosomal lumen pH elevation | IDA | biological_process |
| GO:0042133 | Neurotransmitter metabolic process | ISS | biological_process |
| GO:0042987 | Amyloid precursor protein catabolic process | IDA | biological_process |
| GO:0043005 | Neuron projection | IDA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | ISS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | ISS | biological_process |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045861 | Negative regulation of proteolysis | ISS | biological_process |
| GO:0047496 | Vesicle transport along microtubule | IMP | biological_process |
| GO:0050885 | Neuromuscular process controlling balance | ISS | biological_process |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0051480 | Cytosolic calcium ion homeostasis | ISS | biological_process |
| GO:0061024 | Membrane organization | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1239584932 | 0.0415706584 | 0.7189756501 | 0.3836592567 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0586241007 |
| GSE13712_SHEAR | Down | -0.2576184994 |
| GSE13712_STATIC | Down | -0.3399510168 |
| GSE19018 | Up | 0.0520596955 |
| GSE19899_A1 | Down | -0.3903927063 |
| GSE19899_A2 | Down | -0.2708001256 |
| PubMed_21979375_A1 | Up | 0.3257196802 |
| PubMed_21979375_A2 | Up | 0.2141896120 |
| GSE35957 | Down | -0.1032953400 |
| GSE36640 | Up | 0.1906226869 |
| GSE54402 | Down | -0.2416514948 |
| GSE9593 | Up | 0.3312391979 |
| GSE43922 | Up | 0.0735875812 |
| GSE24585 | Down | -0.5764584224 |
| GSE37065 | Up | 0.1413710588 |
| GSE28863_A1 | Up | 1.6645411458 |
| GSE28863_A2 | Down | -2.2930425038 |
| GSE28863_A3 | Down | -0.2790111560 |
| GSE28863_A4 | Up | 0.0538614210 |
| GSE48662 | Up | 0.5533891403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025765 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037057 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
