HCSGD entry for CLK2
1. General information
| Official gene symbol | CLK2 |
|---|---|
| Entrez ID | 1196 |
| Gene full name | CDC-like kinase 2 |
| Other gene symbols | hCLK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0010212 | Response to ionizing radiation | IMP | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0043484 | Regulation of RNA splicing | IDA | biological_process |
| GO:0045721 | Negative regulation of gluconeogenesis | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8721558527 | 0.0604856198 | 0.9999902473 | 0.4629984021 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3191452766 |
| GSE13712_SHEAR | Down | -0.3536134125 |
| GSE13712_STATIC | Down | -0.7168864728 |
| GSE19018 | Down | -0.5495700518 |
| GSE19899_A1 | Down | -0.3422980046 |
| GSE19899_A2 | Down | -0.3778790039 |
| PubMed_21979375_A1 | Down | -0.2841255851 |
| PubMed_21979375_A2 | Up | 0.4279685581 |
| GSE35957 | Down | -0.7661692778 |
| GSE36640 | Up | 0.3522462611 |
| GSE54402 | Up | 0.0669824222 |
| GSE9593 | Down | -0.5007377474 |
| GSE43922 | Down | -0.0800309096 |
| GSE24585 | Up | 0.1093471145 |
| GSE37065 | Down | -0.0815898189 |
| GSE28863_A1 | Down | -0.0294478820 |
| GSE28863_A2 | Up | 0.1091369450 |
| GSE28863_A3 | Up | 0.0768451111 |
| GSE28863_A4 | Down | -0.0339882117 |
| GSE48662 | Up | 0.0622669844 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
