HCSGD entry for CLK1
1. General information
| Official gene symbol | CLK1 |
|---|---|
| Entrez ID | 1195 |
| Gene full name | CDC-like kinase 1 |
| Other gene symbols | CLK CLK/STY STY |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0043484 | Regulation of RNA splicing | IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9855201930 | 0.0065335208 | 0.9999902473 | 0.1636646226 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2432701012 |
| GSE13712_SHEAR | Up | 0.7284409863 |
| GSE13712_STATIC | Down | -0.8266624500 |
| GSE19018 | Down | -1.2224139296 |
| GSE19899_A1 | Down | -0.3700337855 |
| GSE19899_A2 | Down | -0.6790049476 |
| PubMed_21979375_A1 | Down | -0.5406090103 |
| PubMed_21979375_A2 | Down | -0.7564725329 |
| GSE35957 | Down | -1.4737692062 |
| GSE36640 | Up | 0.2246310696 |
| GSE54402 | Down | -0.2423430691 |
| GSE9593 | Down | -0.2768608431 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2789225330 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Debromohymenialdisine | DB04367 | EXPT01124 |
| ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | DB08691 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024633 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026392 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045167 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
