HCSGD entry for CLIC2
1. General information
| Official gene symbol | CLIC2 |
|---|---|
| Entrez ID | 1193 |
| Gene full name | chloride intracellular channel 2 |
| Other gene symbols | CLIC2b MRXS32 XAP121 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004364 | Glutathione transferase activity | IDA | molecular_function |
| GO:0004602 | Glutathione peroxidase activity | IDA | molecular_function |
| GO:0005247 | Voltage-gated chloride channel activity | IEA | molecular_function |
| GO:0005254 | Chloride channel activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0010880 | Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IDA | biological_process |
| GO:0010881 | Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IC | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0034707 | Chloride channel complex | IEA | cellular_component |
| GO:0051099 | Positive regulation of binding | IDA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
| GO:0060315 | Negative regulation of ryanodine-sensitive calcium-release channel activity | IDA | biological_process |
| GO:1902476 | Chloride transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1389810759 | 0.2086193952 | 0.7499222837 | 0.8842304509 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5115198205 |
| GSE13712_SHEAR | Down | -4.0207794027 |
| GSE13712_STATIC | Down | -0.4245650766 |
| GSE19018 | Up | 0.0304405804 |
| GSE19899_A1 | Down | -0.0885865100 |
| GSE19899_A2 | Up | 0.0124860109 |
| PubMed_21979375_A1 | Down | -0.3284520988 |
| PubMed_21979375_A2 | Up | 0.3016158691 |
| GSE35957 | Down | -0.0970954487 |
| GSE36640 | Up | 0.2353613184 |
| GSE54402 | Down | -0.1374174316 |
| GSE9593 | Up | 0.4960073363 |
| GSE43922 | Up | 0.2670413501 |
| GSE24585 | Up | 0.2416206592 |
| GSE37065 | Up | 1.1953373456 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0777321153 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017468 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029268 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
