HCSGD entry for CLIC1
1. General information
| Official gene symbol | CLIC1 |
|---|---|
| Entrez ID | 1192 |
| Gene full name | chloride intracellular channel 1 |
| Other gene symbols | G6 NCC27 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005247 | Voltage-gated chloride channel activity | IEA | molecular_function |
| GO:0005254 | Chloride channel activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005903 | Brush border | TAS | cellular_component |
| GO:0006821 | Chloride transport | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0034707 | Chloride channel complex | IEA | cellular_component |
| GO:0045669 | Positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051881 | Regulation of mitochondrial membrane potential | IEA | biological_process |
| GO:0055085 | Transmembrane transport | IDA | biological_process |
| GO:1902476 | Chloride transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1365343718 | 0.8575591923 | 0.7450889142 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4935495020 |
| GSE13712_SHEAR | Up | 0.1297927200 |
| GSE13712_STATIC | Up | 0.2087717100 |
| GSE19018 | Up | 0.4382052964 |
| GSE19899_A1 | Up | 0.0192019132 |
| GSE19899_A2 | Up | 0.2601833499 |
| PubMed_21979375_A1 | Up | 0.7019246739 |
| PubMed_21979375_A2 | Up | 0.0583171555 |
| GSE35957 | Down | -0.4395092274 |
| GSE36640 | Down | -0.2182369272 |
| GSE54402 | Up | 0.4341598726 |
| GSE9593 | Up | 0.0061163782 |
| GSE43922 | Up | 0.1327392707 |
| GSE24585 | Down | -0.1777502509 |
| GSE37065 | Up | 0.0974484919 |
| GSE28863_A1 | Down | -0.0245517547 |
| GSE28863_A2 | Up | 0.1582015259 |
| GSE28863_A3 | Down | -0.3918886604 |
| GSE28863_A4 | Down | -0.0089684758 |
| GSE48662 | Down | -0.2536373878 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004124 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT004186 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038595 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-3p | MIMAT0004560 | MIRT038667 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046924 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049437 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050364 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
