HCSGD entry for CLCN7

1. General information

Official gene symbolCLCN7
Entrez ID1186
Gene full namechloride channel, voltage-sensitive 7
Other gene symbolsCLC-7 CLC7 OPTA2 OPTB4 PPP1R63
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005254Chloride channel activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005765Lysosomal membraneIDA TAScellular_component
GO:0006810TransportTASbiological_process
GO:0009268Response to pHIEAbiological_process
GO:0015297Antiporter activityIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030554Adenyl nucleotide bindingIEAmolecular_function
GO:0031410Cytoplasmic vesicleIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00777036590.99483359670.22846272321.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2887061289
GSE13712_SHEARDown-0.1393324738
GSE13712_STATICUp0.1116383747
GSE19018Up0.0962042425
GSE19899_A1Up0.2732422837
GSE19899_A2Up0.6956089831
PubMed_21979375_A1Up0.4278571761
PubMed_21979375_A2Up0.9423161022
GSE35957Down-0.0260010361
GSE36640Up0.4076269585
GSE54402Up0.1418129904
GSE9593Up0.8681509031
GSE43922Up0.5289701749
GSE24585Up0.2369925631
GSE37065Down-0.2062719983
GSE28863_A1Up0.2910021268
GSE28863_A2Up0.6284902040
GSE28863_A3Up0.3744595904
GSE28863_A4Up0.0592207354
GSE48662Up0.4514543981

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-769-3pMIMAT0003887MIRT039129CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-5pMIMAT0000443MIRT045747CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.