HCSGD entry for RFFL

1. General information

Official gene symbolRFFL
Entrez ID117584
Gene full namering finger and FYVE-like domain containing E3 ubiquitin protein ligase
Other gene symbolsCARP-2 CARP2 FRING RIFIFYLIN RNF189 RNF34L
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIDAcellular_component
GO:0002020Protease bindingIPImolecular_function
GO:0002039P53 bindingIPImolecular_function
GO:0002947Tumor necrosis factor receptor superfamily complexIDAcellular_component
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIDA IMPbiological_process
GO:0006886Intracellular protein transportIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010008Endosome membraneIDAcellular_component
GO:0010762Regulation of fibroblast migrationISSbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIMPbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032006Regulation of TOR signalingICbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:1901797Negative regulation of signal transduction by p53 class mediatorIMPbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:2001271Negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87041550090.29788590860.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0652486304
GSE13712_SHEARUp0.1053189322
GSE13712_STATICUp0.0816817915
GSE19018Down-0.0645190152
GSE19899_A1Up0.1101567057
GSE19899_A2Down-0.0284975510
PubMed_21979375_A1Down-0.7130632917
PubMed_21979375_A2Down-0.3044336786
GSE35957Down-0.0184266229
GSE36640Down-0.6726721380
GSE54402Up0.0727173916
GSE9593Up0.0475683783
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0718057164
GSE28863_A2Down-0.2465778389
GSE28863_A3Down-0.3515957174
GSE28863_A4Up0.2797837425
GSE48662Up0.3003991790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002905MicroarrayFunctional MTI (Weak)18668037
hsa-miR-7-5pMIMAT0000252MIRT025938MicroarrayFunctional MTI (Weak)19073608
hsa-miR-92a-3pMIMAT0000092MIRT049627CLASH//Luciferase reporter assayFunctional MTI23622248
hsa-let-7b-5pMIMAT0000063MIRT052109CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.