HCSGD entry for AP2M1
1. General information
| Official gene symbol | AP2M1 |
|---|---|
| Entrez ID | 1173 |
| Gene full name | adaptor-related protein complex 2, mu 1 subunit |
| Other gene symbols | AP50 CLAPM1 mu2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005905 | Coated pit | IEA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0030131 | Clathrin adaptor complex | IEA | cellular_component |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0030669 | Clathrin-coated endocytic vesicle membrane | TAS | cellular_component |
| GO:0042059 | Negative regulation of epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0050690 | Regulation of defense response to virus by virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1906521181 | 0.5896417993 | 0.8480371684 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1326899585 |
| GSE13712_SHEAR | Up | 0.0336431797 |
| GSE13712_STATIC | Up | 0.0676436828 |
| GSE19018 | Up | 0.6759450820 |
| GSE19899_A1 | Down | -0.0929024788 |
| GSE19899_A2 | Up | 0.2870555903 |
| PubMed_21979375_A1 | Down | -0.2532153868 |
| PubMed_21979375_A2 | Up | 0.3933109841 |
| GSE35957 | Up | 0.0633698002 |
| GSE36640 | Up | 0.5013322210 |
| GSE54402 | Up | 0.4033144725 |
| GSE9593 | Down | -0.0432410523 |
| GSE43922 | Down | -0.0235437222 |
| GSE24585 | Up | 0.2127901123 |
| GSE37065 | Down | -0.3789032263 |
| GSE28863_A1 | Up | 0.0050164330 |
| GSE28863_A2 | Down | -0.0682279425 |
| GSE28863_A3 | Down | -0.4059609642 |
| GSE28863_A4 | Down | -0.2517560656 |
| GSE48662 | Up | 0.0416943048 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT003232 | Luciferase reporter assay | Functional MTI | 20065103 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025242 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031416 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036371 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036491 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041965 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042462 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046490 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | NA | hsa-miR-224 | 20065103 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
