HCSGD entry for ERCC8
1. General information
| Official gene symbol | ERCC8 |
|---|---|
| Entrez ID | 1161 |
| Gene full name | excision repair cross-complementing rodent repair deficiency, complementation group 8 |
| Other gene symbols | CKN1 CSA UVSS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000109 | Nucleotide-excision repair complex | IDA | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003678 | DNA helicase activity | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | IDA IMP TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IMP TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0006979 | Response to oxidative stress | IDA IMP | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0009411 | Response to UV | IDA IEA IMP | biological_process |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0031464 | Cul4A-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0045739 | Positive regulation of DNA repair | IMP | biological_process |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9839865203 | 0.0446912731 | 0.9999902473 | 0.3978082516 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0827658927 |
| GSE13712_SHEAR | Down | -0.2347676604 |
| GSE13712_STATIC | Down | -0.2039444252 |
| GSE19018 | Down | -0.0339627031 |
| GSE19899_A1 | Down | -0.1452643185 |
| GSE19899_A2 | Down | -0.2916698036 |
| PubMed_21979375_A1 | Down | -0.0213161228 |
| PubMed_21979375_A2 | Down | -1.0725799894 |
| GSE35957 | Down | -0.0890510904 |
| GSE36640 | Down | -0.5539032612 |
| GSE54402 | Down | -0.1496056461 |
| GSE9593 | Down | -0.1941718295 |
| GSE43922 | Down | -0.0452131634 |
| GSE24585 | Down | -0.0689661255 |
| GSE37065 | Down | -0.1159609950 |
| GSE28863_A1 | Down | -0.1180677978 |
| GSE28863_A2 | Down | -0.2152928055 |
| GSE28863_A3 | Down | -0.5642273230 |
| GSE28863_A4 | Up | 0.0064269102 |
| GSE48662 | Down | -0.1294122281 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-521 | MIMAT0002854 | MIRT005022 | Western blot | Functional MTI | 18668526 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029207 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
