HCSGD entry for ADCYAP1

1. General information

Official gene symbolADCYAP1
Entrez ID116
Gene full nameadenylate cyclase activating polypeptide 1 (pituitary)
Other gene symbolsPACAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0001662Behavioral fear responseIEAbiological_process
GO:0001821Histamine secretionIEAbiological_process
GO:0002865Negative regulation of acute inflammatory response to antigenic stimulusIEAbiological_process
GO:0002878Negative regulation of acute inflammatory response to non-antigenic stimulusIEAbiological_process
GO:0005057Receptor signaling protein activityIEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005184Neuropeptide hormone activityIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007218Neuropeptide signaling pathwayIDAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007565Female pregnancyTASbiological_process
GO:0008277Regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010579Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0010656Negative regulation of muscle cell apoptotic processIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0016521Pituitary adenylate cyclase activating polypeptide activityIDAmolecular_function
GO:0019233Sensory perception of painIEAbiological_process
GO:0019933CAMP-mediated signalingIMPbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0031175Neuron projection developmentIDAbiological_process
GO:0031858Pituitary adenylate cyclase-activating polypeptide receptor bindingIEAmolecular_function
GO:0032755Positive regulation of interleukin-6 productionIEAbiological_process
GO:0032854Positive regulation of Rap GTPase activityIDAbiological_process
GO:0032880Regulation of protein localizationIDAbiological_process
GO:0034259Negative regulation of Rho GTPase activityIEAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0043195Terminal boutonIEAcellular_component
GO:0043267Negative regulation of potassium ion transportIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045786Negative regulation of cell cycleIEAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046034ATP metabolic processIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051428Peptide hormone receptor bindingIDA IPImolecular_function
GO:0051968Positive regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0060078Regulation of postsynaptic membrane potentialIEAbiological_process
GO:0060124Positive regulation of growth hormone secretionIEAbiological_process
GO:0060253Negative regulation of glial cell proliferationIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070445Regulation of oligodendrocyte progenitor proliferationIEAbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:0090274Positive regulation of somatostatin secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64530089280.75997889520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0002430638
GSE13712_SHEARDown-0.0270865463
GSE13712_STATICDown-0.0442516898
GSE19018Up0.0475795542
GSE19899_A1Up0.1416895985
GSE19899_A2Up0.1891234643
PubMed_21979375_A1Up0.2569593215
PubMed_21979375_A2Down-0.0102830436
GSE35957Up0.2210693346
GSE36640Up0.0878474223
GSE54402Up0.0208131492
GSE9593Up0.0355294602
GSE43922Up0.0244026174
GSE24585Down-0.0000956052
GSE37065Down-0.0622824067
GSE28863_A1Down-0.1243513374
GSE28863_A2Down-0.5247401977
GSE28863_A3Up0.1935179178
GSE28863_A4Up0.0380538245
GSE48662Up0.0937985475

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2,6-Diamino-Hexanoic Acid AmideDB03988 EXPT02078

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.