HCSGD entry for CKB
1. General information
| Official gene symbol | CKB |
|---|---|
| Entrez ID | 1152 |
| Gene full name | creatine kinase, brain |
| Other gene symbols | B-CK CKBB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004111 | Creatine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006600 | Creatine metabolic process | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030644 | Cellular chloride ion homeostasis | IEA | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0376993693 | 0.2520290414 | 0.4383170861 | 0.9643270113 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.4270758681 |
| GSE13712_SHEAR | Down | -0.6535994458 |
| GSE13712_STATIC | Down | -0.2307991401 |
| GSE19018 | Up | 0.1721594894 |
| GSE19899_A1 | Down | -0.4186641910 |
| GSE19899_A2 | Up | 0.8500027602 |
| PubMed_21979375_A1 | Up | 0.5614632976 |
| PubMed_21979375_A2 | Up | 0.5229545849 |
| GSE35957 | Up | 0.4796994075 |
| GSE36640 | Down | -0.0288503868 |
| GSE54402 | Down | -0.0285378538 |
| GSE9593 | Up | 1.0399580639 |
| GSE43922 | Down | -0.4873167274 |
| GSE24585 | Down | -0.1547471069 |
| GSE37065 | Up | 0.7128140000 |
| GSE28863_A1 | Down | -0.1706103813 |
| GSE28863_A2 | Down | -0.1354907004 |
| GSE28863_A3 | Down | -0.0044550901 |
| GSE28863_A4 | Up | 0.1426246046 |
| GSE48662 | Down | -0.0154838019 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-935 | MIMAT0004978 | MIRT036653 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037448 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042674 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-346 | MIMAT0000773 | MIRT042718 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043074 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044642 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049124 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052190 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052723 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21980054 | Among two isozymes, brain-type CK (CKB) is the predominant CK in lung tissue |
| 21980054 | In this study, we investigated the role of CKB in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBECs) |
| 21980054 | CKB inhibition was examined by small interfering RNA and cyclocreatine |
| 21980054 | CSE induced carbonylation of CKB and subsequently decreased CKB protein levels, which was reversed by a proteasome inhibitor |
| 21980054 | CKB inhibition alone induced cell senescence, and further enhanced CSE-induced cell senescence and IL-8 secretion |
| 21980054 | CSE-induced oxidation of CKB is a trigger for proteasomal degradation |
| 20721618 | RESULTS: CKB and PRDX2 were up-regulated in women older than 38 years, and the expression of these genes in cumulus cells was associated with embryo quality |
| 20721618 | In good-quality embryos, CKB expression was higher in the cumulus cells acquired from both older and younger age groups than in poor-quality embryos |
| 20721618 | CKB and PRDX2 may serve as biomarkers or therapeutic targets for the developmental potential of oocytes |
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