HCSGD entry for NLRP3

1. General information

Official gene symbolNLRP3
Entrez ID114548
Gene full nameNLR family, pyrin domain containing 3
Other gene symbolsAGTAVPRL AII AVP C1orf7 CIAS1 CLR1.1 FCAS FCU MWS NALP3 PYPAF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002674Negative regulation of acute inflammatory responseIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processNASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0006952Defense responseTASbiological_process
GO:0006954Inflammatory responseIMPbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0009595Detection of biotic stimulusTASbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032611Interleukin-1 beta productionIEAbiological_process
GO:0032621Interleukin-18 productionIEAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0042347Negative regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042834Peptidoglycan bindingTASmolecular_function
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0044546NLRP3 inflammasome complex assemblyIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050701Interleukin-1 secretionIEAbiological_process
GO:0050713Negative regulation of interleukin-1 beta secretionIMPbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionIDAbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051259Protein oligomerizationTASbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIMPbiological_process
GO:0072559NLRP3 inflammasome complexIDAcellular_component
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48292793970.92025578820.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0693164857
GSE13712_SHEARDown-0.0633460122
GSE13712_STATICDown-0.0864531507
GSE19018Up0.1783539686
GSE19899_A1Up0.0417090372
GSE19899_A2Up0.4795661902
PubMed_21979375_A1Up0.4205580381
PubMed_21979375_A2Up0.2291006104
GSE35957Up0.0129073384
GSE36640Up0.0975973264
GSE54402Up0.0512650527
GSE9593Up0.0106513855
GSE43922Up0.0426937291
GSE24585Down-0.0679344245
GSE37065Down-0.0467112339
GSE28863_A1Down-0.1817526091
GSE28863_A2Up0.1679099684
GSE28863_A3Up0.1806457402
GSE28863_A4Up0.1430711219
GSE48662Down-0.1923430438

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016468MicroarrayFunctional MTI (Weak)20304954
hsa-miR-100-5pMIMAT0000098MIRT048559CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26164602Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome
26164602We have discovered that the PSPC down-regulates reactive oxygen species (ROS) accumulation and the NLRP3 inflammasome functions
26164602Furthermore, the premature senescence induced by D-gal was inhibited after attenuation of ROS and deactivation of NLRP3 inflammasomes
26164602However, once the NLRP3 inflammasomes are overactivated, PSPC could not restrain cell senescence
26164602These data imply that the beneficial effects of PSPC on diabetes-induced endothelial dysfunction and senescence are mediated through ROS and NLRP3 signaling pathways, suggesting a potential target for the prevention of endothelial senescence-related cardiovascular diseases
25628952Aging-related gene signature regulated by Nlrp3 predicts glioma progression
25628952Recently, Nlrp3 inflammasome have been shown to modulate several major cellular pathways such as inflammation and cell death and have been demonstrated to be an upstream target that controlled the process of brain aging
25628952We proposed Nlrp3 inflammasome may serve as a possible molecular link between aging and glioma progression
25628952In this study, we generated a aging-related gene signature that regulated by Nlrp3 in mouse hippocampus and demonstrated that this gene signature can distinguish subsets of glioma samples and predicts clinical outcome in radiotherapy-treated patients
25628952Ionizing radiation can induce Nlrp3 inflammasome expression; Nlrp3 inhibition reduced tumor growth and prolonged the survival of mouse following IR treatment; Nlrp3 inhibition reduced number of senescent cells induced by IR
25628952These results above suggest that Nlrp3 inflammasome is an important molecular link between brain aging and glioma progression; the Nlrp3 gene signature may serve as a predictive biomarker for glioma patients
Entries Per Page
Displaying Page of