HCSGD entry for CHRNB2

1. General information

Official gene symbolCHRNB2
Entrez ID1141
Gene full namecholinergic receptor, nicotinic, beta 2 (neuronal)
Other gene symbolsEFNL3 nAChRB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialIEAbiological_process
GO:0001661Conditioned taste aversionIEAbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIDA TASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005892Acetylcholine-gated channel complexIDAcellular_component
GO:0006811Ion transportNASbiological_process
GO:0006816Calcium ion transportISSbiological_process
GO:0006939Smooth muscle contractionISSbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007271Synaptic transmission, cholinergicISSbiological_process
GO:0007601Visual perceptionISSbiological_process
GO:0007605Sensory perception of soundISSbiological_process
GO:0007612LearningIMPbiological_process
GO:0007613MemoryIMPbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008306Associative learningISSbiological_process
GO:0008542Visual learningIMPbiological_process
GO:0009897External side of plasma membraneISScellular_component
GO:0014059Regulation of dopamine secretionISSbiological_process
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0015464Acetylcholine receptor activityIDAmolecular_function
GO:0016021Integral component of membraneNAScellular_component
GO:0019233Sensory perception of painISSbiological_process
GO:0021562Vestibulocochlear nerve developmentISSbiological_process
GO:0021631Optic nerve morphogenesisISSbiological_process
GO:0021771Lateral geniculate nucleus developmentISSbiological_process
GO:0021952Central nervous system projection neuron axonogenesisISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030890Positive regulation of B cell proliferationISSbiological_process
GO:0032225Regulation of synaptic transmission, dopaminergicISSbiological_process
GO:0032226Positive regulation of synaptic transmission, dopaminergicIEAbiological_process
GO:0033603Positive regulation of dopamine secretionISSbiological_process
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035094Response to nicotineIDAbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0035176Social behaviorISSbiological_process
GO:0042053Regulation of dopamine metabolic processISSbiological_process
GO:0042113B cell activationISSbiological_process
GO:0042166Acetylcholine bindingIC IMPmolecular_function
GO:0042220Response to cocaineISSbiological_process
GO:0042320Regulation of circadian sleep/wake cycle, REM sleepISSbiological_process
GO:0045188Regulation of circadian sleep/wake cycle, non-REM sleepIEAbiological_process
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0045471Response to ethanolISSbiological_process
GO:0045759Negative regulation of action potentialISSbiological_process
GO:0048814Regulation of dendrite morphogenesisISSbiological_process
GO:0050877Neurological system processIMPbiological_process
GO:0050890CognitionIMPbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051899Membrane depolarizationISSbiological_process
GO:0051963Regulation of synapse assemblyISSbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060084Synaptic transmission involved in micturitionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90737250860.27614750580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1034677628
GSE13712_SHEARDown-0.0167173792
GSE13712_STATICDown-0.0031306558
GSE19018Up0.0474464347
GSE19899_A1Down-0.0971568819
GSE19899_A2Up0.2265211799
PubMed_21979375_A1Up0.0183936038
PubMed_21979375_A2Down-0.0602200507
GSE35957Up0.1931558257
GSE36640Down-0.0444277438
GSE54402Up0.1125824772
GSE9593Down-0.2655710657
GSE43922Up0.0884060663
GSE24585Down-0.0975590697
GSE37065Down-0.0082463251
GSE28863_A1Down-0.3815183648
GSE28863_A2Down-0.3640608417
GSE28863_A3Up0.0461750181
GSE28863_A4Down-0.1442796263
GSE48662Up0.0394041581

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
ABT-089DB05458 -
RPI-78MDB05740 -
RivaniclineDB05855 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.