HCSGD entry for CHRNA2
1. General information
| Official gene symbol | CHRNA2 |
|---|---|
| Entrez ID | 1135 |
| Gene full name | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004889 | Acetylcholine-activated cation-selective channel activity | IDA IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005892 | Acetylcholine-gated channel complex | IDA IEA | cellular_component |
| GO:0006811 | Ion transport | NAS | biological_process |
| GO:0006812 | Cation transport | IDA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008144 | Drug binding | IEA | molecular_function |
| GO:0015464 | Acetylcholine receptor activity | IDA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA NAS | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | IDA | biological_process |
| GO:0042166 | Acetylcholine binding | IEA | molecular_function |
| GO:0045211 | Postsynaptic membrane | IEA | cellular_component |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
| GO:0055085 | Transmembrane transport | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1557153832 | 0.8982541507 | 0.7838180532 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1027664717 |
| GSE13712_SHEAR | Up | 0.0668495649 |
| GSE13712_STATIC | Up | 0.3608979273 |
| GSE19018 | Up | 0.2346971627 |
| GSE19899_A1 | Down | -0.0163544443 |
| GSE19899_A2 | Up | 0.1320056959 |
| PubMed_21979375_A1 | Down | -0.2060291476 |
| PubMed_21979375_A2 | Down | -0.0305036972 |
| GSE35957 | Up | 0.6009863636 |
| GSE36640 | Up | 0.2173831554 |
| GSE54402 | Up | 0.0711004282 |
| GSE9593 | Down | -0.0524598964 |
| GSE43922 | Up | 0.0276466011 |
| GSE24585 | Down | -0.0386992904 |
| GSE37065 | Up | 0.0028098043 |
| GSE28863_A1 | Down | -0.0778465146 |
| GSE28863_A2 | Down | -0.1089084396 |
| GSE28863_A3 | Up | 0.3486509534 |
| GSE28863_A4 | Up | 0.5329895836 |
| GSE48662 | Up | 0.0336422781 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nicotine | DB00184 | APRD00200 | EXPT02315 | DB09463 |
| Gallamine Triethiodide | DB00483 | APRD00712 |
| Dextromethorphan | DB00514 | APRD00655 |
| Mecamylamine | DB00657 | APRD00458 |
| Galantamine | DB00674 | APRD00206 | EXPT01628 |
| Rocuronium | DB00728 | APRD01221 |
| Biperiden | DB00810 | APRD00725 |
| Doxacurium chloride | DB01135 | APRD00934 | DB01334 |
| Tubocurarine | DB01199 | APRD00176 |
| Mivacurium | DB01226 | APRD01119 |
| Decamethonium | DB01245 | APRD00696 |
| Metocurine | DB01336 | - |
| Pancuronium | DB01337 | - |
| Pipecuronium | DB01338 | - |
| Vecuronium | DB01339 | - |
| RPI-78M | DB05740 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025736 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
