HCSGD entry for TWF2
1. General information
| Official gene symbol | TWF2 |
|---|---|
| Entrez ID | 11344 |
| Gene full name | twinfilin actin-binding protein 2 |
| Other gene symbols | A6RP A6r PTK9L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0003785 | Actin monomer binding | ISS | molecular_function |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | ISS | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0010592 | Positive regulation of lamellipodium assembly | IMP | biological_process |
| GO:0010976 | Positive regulation of neuron projection development | IMP | biological_process |
| GO:0030016 | Myofibril | ISS | cellular_component |
| GO:0030027 | Lamellipodium | ISS | cellular_component |
| GO:0030030 | Cell projection organization | IEA | biological_process |
| GO:0030175 | Filopodium | ISS | cellular_component |
| GO:0030426 | Growth cone | IDA | cellular_component |
| GO:0030837 | Negative regulation of actin filament polymerization | IEA ISS | biological_process |
| GO:0032420 | Stereocilium | ISS | cellular_component |
| GO:0032532 | Regulation of microvillus length | IC | biological_process |
| GO:0032956 | Regulation of actin cytoskeleton organization | IMP | biological_process |
| GO:0042989 | Sequestering of actin monomers | ISS | biological_process |
| GO:0045773 | Positive regulation of axon extension | IMP | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
| GO:0051016 | Barbed-end actin filament capping | ISS | biological_process |
| GO:0071300 | Cellular response to retinoic acid | IMP | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3509501615 | 0.5723596444 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1180007941 |
| GSE13712_SHEAR | Up | 0.1410134348 |
| GSE13712_STATIC | Down | -0.0161893239 |
| GSE19018 | Up | 0.1398780085 |
| GSE19899_A1 | Down | -0.2169765202 |
| GSE19899_A2 | Up | 0.3099433091 |
| PubMed_21979375_A1 | Up | 0.6165384751 |
| PubMed_21979375_A2 | Down | -0.2999692337 |
| GSE35957 | Down | -0.2728776220 |
| GSE36640 | Down | -0.2172163983 |
| GSE54402 | Up | 0.3645212919 |
| GSE9593 | Up | 0.1248352740 |
| GSE43922 | Up | 0.1701876074 |
| GSE24585 | Up | 0.0902915852 |
| GSE37065 | Down | -0.2775205044 |
| GSE28863_A1 | Up | 0.0236664172 |
| GSE28863_A2 | Down | -0.1949240839 |
| GSE28863_A3 | Down | -0.3657030519 |
| GSE28863_A4 | Down | -0.0833826061 |
| GSE48662 | Up | 0.3225473019 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT005539 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blot | Non-Functional MTI | 20571053 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT005540 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blot | Non-Functional MTI | 20571053 |
| hsa-miR-484 | MIMAT0002174 | MIRT042297 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
