HCSGD entry for CHRNA1

1. General information

Official gene symbolCHRNA1
Entrez ID1134
Gene full namecholinergic receptor, nicotinic, alpha 1 (muscle)
Other gene symbolsACHRA ACHRD CHRNA CMS2A FCCMS SCCMS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003009Skeletal muscle contractionIMPbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIEA IMP ISSmolecular_function
GO:0005216Ion channel activityTASmolecular_function
GO:0005230Extracellular ligand-gated ion channel activityIEAmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005892Acetylcholine-gated channel complexISScellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportIMP ISS TASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007274Neuromuscular synaptic transmissionIMPbiological_process
GO:0007528Neuromuscular junction developmentIMPbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015464Acetylcholine receptor activityISSmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0019228Neuronal action potentialIMPbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0031594Neuromuscular junctionIDA ISScellular_component
GO:0034220Ion transmembrane transportIMP ISS TASbiological_process
GO:0042166Acetylcholine bindingISSmolecular_function
GO:0042391Regulation of membrane potentialIMPbiological_process
GO:0045211Postsynaptic membraneIEA NAScellular_component
GO:0046716Muscle cell cellular homeostasisIMPbiological_process
GO:0048630Skeletal muscle tissue growthIMPbiological_process
GO:0050881Musculoskeletal movementIMPbiological_process
GO:0050905Neuromuscular processIMPbiological_process
GO:0055085Transmembrane transportIMP ISS TASbiological_process
GO:0070050Neuron cellular homeostasisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00603383990.98440817980.20492477421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0120094174
GSE13712_SHEARUp0.0335573167
GSE13712_STATICDown-0.3558361183
GSE19018Down-0.0301688596
GSE19899_A1Up0.5915311257
GSE19899_A2Up1.7627370358
PubMed_21979375_A1Up1.4349742798
PubMed_21979375_A2Up2.0106949548
GSE35957Down-0.0671194813
GSE36640Up0.5719929775
GSE54402Up0.2605877732
GSE9593Down-0.0204071448
GSE43922Up2.3780626991
GSE24585Up0.0870397693
GSE37065Down-0.0111250145
GSE28863_A1Up0.1181016103
GSE28863_A2Up0.0303785081
GSE28863_A3Up0.1598443124
GSE28863_A4Up0.2327786005
GSE48662Up0.1152241515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GalantamineDB00674 APRD00206 | EXPT01628
AgmatineDB08838 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.