HCSGD entry for CBX3
1. General information
| Official gene symbol | CBX3 |
|---|---|
| Entrez ID | 11335 |
| Gene full name | chromobox homolog 3 |
| Other gene symbols | HECH HP1-GAMMA HP1Hs-gamma |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000779 | Condensed chromosome, centromeric region | ISS | cellular_component |
| GO:0000785 | Chromatin | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005635 | Nuclear envelope | ISS | cellular_component |
| GO:0005637 | Nuclear inner membrane | NAS | cellular_component |
| GO:0005719 | Nuclear euchromatin | IDA | cellular_component |
| GO:0005720 | Nuclear heterochromatin | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0006338 | Chromatin remodeling | NAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0031618 | Nuclear centromeric heterochromatin | ISS | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:1990226 | Histone methyltransferase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9910794841 | 0.0469863721 | 0.9999902473 | 0.4069523857 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0429357413 |
| GSE13712_SHEAR | Up | 0.3246343676 |
| GSE13712_STATIC | Down | -0.1800587259 |
| GSE19018 | Down | -0.1141839360 |
| GSE19899_A1 | Down | -0.1321943756 |
| GSE19899_A2 | Down | -0.2138103563 |
| PubMed_21979375_A1 | Down | -0.1376087171 |
| PubMed_21979375_A2 | Down | -0.2439272428 |
| GSE35957 | Down | -0.4082582198 |
| GSE36640 | Down | -0.8250332517 |
| GSE54402 | Down | -0.1234748994 |
| GSE9593 | Down | -0.2582946950 |
| GSE43922 | Down | -0.1156994407 |
| GSE24585 | Up | 0.0477490243 |
| GSE37065 | Down | -0.1005454419 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.4713475162 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148a-3p | MIMAT0000243 | MIRT025978 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-935 | MIMAT0004978 | MIRT036684 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045000 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048414 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048788 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26718972 | Deletion of AMPKalpha2, the minor isoform of AMPKalpha, but not AMPKalpha1 in high-passaged MEFs led to spontaneous cell senescence demonstrated by accumulation of senescence-associated-beta-galactosidase (SA-beta-gal) staining and foci formation of heterochromatin protein 1 homolog gamma (HP1gamma) |
| 26215037 | Western blot was used to assess SHP-1, p21, p53, pRb, Rb, H3K9Me3, HP1gamma, CDK4, cyclin D1, cyclin E, and p16 protein expressions |
| 25876105 | FFPE tissue microarrays were subjected to immunofluorescent staining for GLB1, Ki67 and HP1gamma and automated quantitative imaging initially using AQUA in exploratory samples and Vectra in a validation series |
| 25040935 | We also revealed that PIM-1 interacts with and phosphorylates heterochromatin protein 1gamma (HP1gamma) on Ser93 |
| 25040935 | This PIM-1-mediated HP1gamma phosphorylation enhanced HP1gamma's capacity to bind to H3K9me3, resulting in heterochromatin formation and suppression of proliferative genes, such as CCNA2 and PCNA |
| 24402692 | The strong positive expressions of the senescence marker CBX3 were 39 |
| 24402692 | For CBX3, such expressions were 7 |
| 24402692 | Results also showed that the expression of Twist was inversely correlated with that of CBX3 |
| 24402692 | Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated beta-galactosidase activity |
| 23184984 | We show here that CD158d agonists trigger a DNA damage response signaling pathway involving cyclin-dependent kinase inhibitor p21 expression and heterochromatin protein HP1-gamma phosphorylation |
| 22970173 | Increased cellular senescence (HP1gamma; P = 0 |
| 22970173 | In contrast to UC, we noted in Crohn's disease (CD) that senescence (HP1gamma; P<0 |
| 22970173 | CONCLUSIONS: Senescence was observed in IBD with senescence-associated beta-galactosidase and HP1gamma |
| 22911222 | The increased expression of the senescence-related proteins Glb1, the cyclin-dependent kinase inhibitor p27(Kip1) and chromatin-regulating heterochromatin protein 1gamma (HP1gamma) were detected in LNCaP cells after AD in vitro by immunoblot and immunofluorescence microscopy |
| 22911222 | In mice bearing LuCaP xenograft tumors in vivo, surgical castration similarly increased SA-beta-gal staining, increased expression of p27(Kip1) and HP1gamma, and decreased expression of the proliferation marker KI-67, with minimal induction of apoptosis identified by detection of cleaved caspase 3 and TUNEL |
| 22911222 | Immunohistochemical analysis of human prostate tumors removed after AD shows similar induction of Glb1, HP1gamma and decreased KI-67 |
| 22606351 | It can be further aided by the transcriptional repression of proliferation-associated genes by the action of HP1gamma, HMGA, and DNMT proteins to produce a repressive chromatin environment |
| 20729911 | Interestingly, TACC3-depleted cells arrested in G(1) through a cellular senescence program characterized by the upregulation of nuclear p21(WAF), downregulation of the retinoblastoma protein and extracellular signal-regulated kinase 1/2, formation of HP1gamma (phospho-Ser83)-positive senescence-associated heterochromatic foci and increased senescence-associated beta-galactosidase activity |
| 20695923 | Heterochromatin marks HP1gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours |
| 20695923 | Here, we show distinct cell-type- and cancer-stage-associated patterns of key heterochromatin marks: histone H3 trimethylated at lysine 9 (H3K9me3) and heterochromatic adaptor proteins HP1alpha and HP1gamma, compared with the gammaH2AX marker of endogenously activated DNA damage response (DDR) and proliferation markers in normal human foetal (n=4) and adult (n=29) testes, pre-invasive carcinoma in situ (CIS; n=26) lesions and a series of overt germ cell tumours, including seminomas (n=26), embryonal carcinomas (n=18) and teratomas (n=11) |
| 20695923 | Among striking findings were high levels of HP1gamma in foetal gonocytes, CIS and seminomas; enhanced multimarker heterochromatinization without DDR activation in CIS; and enhanced HP1alpha in teratoma structures with epithelial and neuronal differentiation |
| 17242207 | In cells entering senescence, HP1gamma, but not the related proteins HP1alpha and HP1beta, becomes phosphorylated on serine 93 |
| 17242207 | This phosphorylation is required for efficient incorporation of HP1gamma into SAHF |
| 16705168 | Prohibitin could bind to heterochromatin protein 1 (HP1) family proteins and colocalized with HP1gamma in senescence-associated heterochromatic foci |
| 16705168 | Further, HP1gamma could synergize with prohibitin to repress E2F1-mediated transcriptional activity |
| 16705168 | Chromatin immunoprecipitation assays showed that prohibitin is needed for the recruitment of HP1gamma to E2F1-regulated proliferative promoters, leading to their repression |
| 16705168 | Prohibitin-mediated recruitment of HP1gamma occurred in only senescent cells, not in quiescent cells; thus, there is a dichotomy in the recruitment of different corepressors by prohibitin, depending on the type of growth arrest |
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