HCSGD entry for TUSC2
1. General information
| Official gene symbol | TUSC2 |
|---|---|
| Entrez ID | 11334 |
| Gene full name | tumor suppressor candidate 2 |
| Other gene symbols | C3orf11 FUS1 PAP PDAP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001779 | Natural killer cell differentiation | IEA | biological_process |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0032618 | Interleukin-15 production | IEA | biological_process |
| GO:0048469 | Cell maturation | IEA | biological_process |
| GO:0051881 | Regulation of mitochondrial membrane potential | IEA | biological_process |
| GO:0071609 | Chemokine (C-C motif) ligand 5 production | IEA | biological_process |
| GO:2000377 | Regulation of reactive oxygen species metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0045200182 | 0.9906591847 | 0.1782794074 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9522077609 |
| GSE13712_SHEAR | Up | 0.1154410956 |
| GSE13712_STATIC | Up | 0.2086228877 |
| GSE19018 | Down | -0.0195142098 |
| GSE19899_A1 | Up | 0.8518910974 |
| GSE19899_A2 | Up | 1.6231530034 |
| PubMed_21979375_A1 | Up | 0.9502431841 |
| PubMed_21979375_A2 | Up | 1.1066704977 |
| GSE35957 | Down | -0.0604678381 |
| GSE36640 | Up | 0.5485055255 |
| GSE54402 | Up | 0.5904765750 |
| GSE9593 | Up | 0.0445132644 |
| GSE43922 | Up | 0.8359923793 |
| GSE24585 | Down | -0.1699331368 |
| GSE37065 | Up | 0.0960280388 |
| GSE28863_A1 | Up | 0.0103876129 |
| GSE28863_A2 | Up | 0.0768926422 |
| GSE28863_A3 | Down | -0.0162320148 |
| GSE28863_A4 | Down | -0.0664038055 |
| GSE48662 | Up | 0.5843212255 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002528 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT003753 | Luciferase reporter assay//Western blot//qRT-PCR | Functional MTI | 18077375 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT004410 | Luciferase reporter assay//Western blot | Functional MTI | 19671678 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT004410 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT004411 | Luciferase reporter assay//Western blot | Functional MTI | 19671678 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT004411 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT004412 | Luciferase reporter assay//Western blot | Functional MTI | 19671678 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT004423 | Reporter assay | Functional MTI | 18077375 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT004959 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021769 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025636 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040404 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049184 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 | |||
| hsa-miR-93-5p | MIMAT0000093 | NA | hsa-miR-93 | {Western blot} | {overexpression} | 19671678 | |
| hsa-miR-98-5p | MIMAT0000096 | NA | hsa-miR-98 | {Western blot} | {overexpression} | 19671678 | |
| hsa-miR-197-3p | MIMAT0000227 | NA | hsa-miR-197 | 19671678 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
