HCSGD entry for PHB2
1. General information
| Official gene symbol | PHB2 |
|---|---|
| Entrez ID | 11331 |
| Gene full name | prohibitin 2 |
| Other gene symbols | BAP BCAP37 Bap37 PNAS-141 REA p22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | ISS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0030331 | Estrogen receptor binding | NAS | molecular_function |
| GO:0033147 | Negative regulation of intracellular estrogen receptor signaling pathway | IEA | biological_process |
| GO:0033600 | Negative regulation of mammary gland epithelial cell proliferation | IEA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0060744 | Mammary gland branching involved in thelarche | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0060762 | Regulation of branching involved in mammary gland duct morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9957748908 | 0.0096754455 | 0.9999902473 | 0.1948280153 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1080356857 |
| GSE13712_SHEAR | Down | -0.4726739651 |
| GSE13712_STATIC | Down | -0.1131382604 |
| GSE19018 | Down | -0.3426461771 |
| GSE19899_A1 | Down | -0.7074792344 |
| GSE19899_A2 | Down | -0.5010694943 |
| PubMed_21979375_A1 | Down | -0.3607569880 |
| PubMed_21979375_A2 | Down | -0.3818530453 |
| GSE35957 | Down | -0.5481129361 |
| GSE36640 | Down | -0.7576224179 |
| GSE54402 | Up | 0.0755436247 |
| GSE9593 | Down | -0.3843493106 |
| GSE43922 | Down | -0.4523241443 |
| GSE24585 | Down | -0.2781762094 |
| GSE37065 | Down | -0.4446531830 |
| GSE28863_A1 | Up | 0.1514695028 |
| GSE28863_A2 | Down | -0.1259687030 |
| GSE28863_A3 | Down | -0.3275179494 |
| GSE28863_A4 | Up | 0.0569988451 |
| GSE48662 | - | - |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028641 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041559 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047600 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050313 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15489194 | Mitochondrial integrity is affected by the PHB1 and PHB2 genes, which encode inner mitochondrial membrane chaperones called prohibitins |
| 9259555 | Deletion of the Saccharomyces cerevisiae homologues, PHB1 and PHB2, results in a decreased replicative lifespan and a defect in mitochondrial membrane potential |
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