HCSGD entry for LYST
1. General information
| Official gene symbol | LYST |
|---|---|
| Entrez ID | 1130 |
| Gene full name | lysosomal trafficking regulator |
| Other gene symbols | CHS CHS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002446 | Neutrophil mediated immunity | IEA | biological_process |
| GO:0002456 | T cell mediated immunity | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | IEA | biological_process |
| GO:0007017 | Microtubule-based process | IEA | biological_process |
| GO:0007040 | Lysosome organization | IEA | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0030595 | Leukocyte chemotaxis | ISS | biological_process |
| GO:0032438 | Melanosome organization | ISS | biological_process |
| GO:0032510 | Endosome to lysosome transport via multivesicular body sorting pathway | IMP | biological_process |
| GO:0032816 | Positive regulation of natural killer cell activation | IEA | biological_process |
| GO:0033299 | Secretion of lysosomal enzymes | IEA | biological_process |
| GO:0033364 | Mast cell secretory granule organization | ISS | biological_process |
| GO:0042267 | Natural killer cell mediated cytotoxicity | IMP | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042742 | Defense response to bacterium | ISS | biological_process |
| GO:0042832 | Defense response to protozoan | ISS | biological_process |
| GO:0043473 | Pigmentation | IMP | biological_process |
| GO:0051607 | Defense response to virus | ISS | biological_process |
| GO:0055091 | Phospholipid homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0116078340 | 0.7417450971 | 0.2718557522 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1135585712 |
| GSE13712_SHEAR | Down | -0.2214634029 |
| GSE13712_STATIC | Down | -0.0054696807 |
| GSE19018 | Up | 0.0703089921 |
| GSE19899_A1 | Up | 0.3175807174 |
| GSE19899_A2 | Up | 0.1981992439 |
| PubMed_21979375_A1 | Up | 0.6623838364 |
| PubMed_21979375_A2 | Up | 0.6478617611 |
| GSE35957 | Up | 0.2674717630 |
| GSE36640 | Up | 0.8977306615 |
| GSE54402 | Up | 0.2296846841 |
| GSE9593 | Up | 0.4672440109 |
| GSE43922 | Up | 0.7060204945 |
| GSE24585 | Up | 0.5085164192 |
| GSE37065 | Up | 0.3400588139 |
| GSE28863_A1 | Up | 0.2581332967 |
| GSE28863_A2 | Up | 0.6718004342 |
| GSE28863_A3 | Down | -1.1657170877 |
| GSE28863_A4 | Down | -0.5753798702 |
| GSE48662 | Up | 0.1962232077 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017524 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028036 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040614 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT044888 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050104 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
