HCSGD entry for PNKP
1. General information
| Official gene symbol | PNKP |
|---|---|
| Entrez ID | 11284 |
| Gene full name | polynucleotide kinase 3'-phosphatase |
| Other gene symbols | EIEE10 MCSZ PNK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | NAS | biological_process |
| GO:0003684 | Damaged DNA binding | NAS | molecular_function |
| GO:0003690 | Double-stranded DNA binding | TAS | molecular_function |
| GO:0004519 | Endonuclease activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | NAS | biological_process |
| GO:0006281 | DNA repair | IGI | biological_process |
| GO:0006979 | Response to oxidative stress | IDA | biological_process |
| GO:0009314 | Response to radiation | NAS TAS | biological_process |
| GO:0016311 | Dephosphorylation | IDA | biological_process |
| GO:0017076 | Purine nucleotide binding | NAS | molecular_function |
| GO:0019201 | Nucleotide kinase activity | IDA | molecular_function |
| GO:0042769 | DNA damage response, detection of DNA damage | IDA NAS | biological_process |
| GO:0046403 | Polynucleotide 3'-phosphatase activity | IDA | molecular_function |
| GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity | IDA | molecular_function |
| GO:0046939 | Nucleotide phosphorylation | IDA | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | NAS | biological_process |
| GO:0098501 | Polynucleotide dephosphorylation | IDA | biological_process |
| GO:0098506 | Polynucleotide 3' dephosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1272031040 | 0.5020252992 | 0.7264293556 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3281639886 |
| GSE13712_SHEAR | Down | -0.4990691434 |
| GSE13712_STATIC | Down | -0.3786845579 |
| GSE19018 | Down | -0.0785565758 |
| GSE19899_A1 | Down | -0.2977495333 |
| GSE19899_A2 | Up | 0.5442030349 |
| PubMed_21979375_A1 | Up | 0.8036050039 |
| PubMed_21979375_A2 | Up | 0.9604178070 |
| GSE35957 | Down | -0.8751226103 |
| GSE36640 | Up | 0.0646451931 |
| GSE54402 | Up | 0.6594483753 |
| GSE9593 | Down | -0.2264302172 |
| GSE43922 | Up | 0.0546282567 |
| GSE24585 | Up | 0.2055881157 |
| GSE37065 | Down | -0.0165584808 |
| GSE28863_A1 | Down | -0.2201449013 |
| GSE28863_A2 | Down | -0.0820573814 |
| GSE28863_A3 | Up | 0.2256305585 |
| GSE28863_A4 | Up | 0.0680667992 |
| GSE48662 | Up | 0.1458074004 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029605 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
