HCSGD entry for KLHL2
1. General information
| Official gene symbol | KLHL2 |
|---|---|
| Entrez ID | 11275 |
| Gene full name | kelch-like family member 2 |
| Other gene symbols | ABP-KELCH MAV MAYVEN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA | cellular_component |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016567 | Protein ubiquitination | IEA ISS | biological_process |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IEA ISS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4589509479 | 0.2068119562 | 0.9999902473 | 0.8813953206 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2242290053 |
| GSE13712_SHEAR | Down | -0.0411146722 |
| GSE13712_STATIC | Up | 0.0596476913 |
| GSE19018 | Down | -0.2716427916 |
| GSE19899_A1 | Down | -0.3199902954 |
| GSE19899_A2 | Down | -0.1627238782 |
| PubMed_21979375_A1 | Up | 0.5131389769 |
| PubMed_21979375_A2 | Down | -0.8229661848 |
| GSE35957 | Up | 0.2845429611 |
| GSE36640 | Up | 0.2810977440 |
| GSE54402 | Up | 0.1234819865 |
| GSE9593 | Up | 0.2290685951 |
| GSE43922 | Down | -0.1769035334 |
| GSE24585 | Up | 0.0662469805 |
| GSE37065 | Up | 0.4162909065 |
| GSE28863_A1 | Up | 0.0538833133 |
| GSE28863_A2 | Up | 0.0705467158 |
| GSE28863_A3 | Up | 0.0603969993 |
| GSE28863_A4 | Down | -0.1354028365 |
| GSE48662 | Down | -0.1593131746 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046342 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
