HCSGD entry for DUSP12
1. General information
| Official gene symbol | DUSP12 |
|---|---|
| Entrez ID | 11266 |
| Gene full name | dual specificity phosphatase 12 |
| Other gene symbols | DUSP1 YVH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006470 | Protein dephosphorylation | IBA | biological_process |
| GO:0007254 | JNK cascade | IRD | biological_process |
| GO:0008138 | Protein tyrosine/serine/threonine phosphatase activity | IBA | molecular_function |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0019900 | Kinase binding | IEA | molecular_function |
| GO:0033133 | Positive regulation of glucokinase activity | IBA | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8257132290 | 0.1122035029 | 0.9999902473 | 0.6420235652 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4677807277 |
| GSE13712_SHEAR | Up | 0.0704851876 |
| GSE13712_STATIC | Down | -0.0037061117 |
| GSE19018 | Down | -0.1276754747 |
| GSE19899_A1 | Down | -0.7328590724 |
| GSE19899_A2 | Down | -0.2630205806 |
| PubMed_21979375_A1 | Down | -0.0070575068 |
| PubMed_21979375_A2 | Down | -0.8262392629 |
| GSE35957 | Down | -0.5440355414 |
| GSE36640 | Down | -0.2400141751 |
| GSE54402 | Up | 0.2092789004 |
| GSE9593 | Down | -0.1257897957 |
| GSE43922 | Down | -0.0914139881 |
| GSE24585 | Up | 0.0863689831 |
| GSE37065 | Down | -0.0515291943 |
| GSE28863_A1 | Up | 0.0917173631 |
| GSE28863_A2 | Up | 0.3822225502 |
| GSE28863_A3 | Up | 0.0655625152 |
| GSE28863_A4 | Down | -0.2754568661 |
| GSE48662 | Down | -0.3073246776 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001636 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030074 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21521943 | The dual-specificity phosphatase hYVH1 (DUSP12) is a novel modulator of cellular DNA content |
| 21521943 | The dual-specificity phosphatase hYVH1 (DUSP12) is an evolutionary conserved phosphatase that also contains a unique zinc-binding domain |
| 21521943 | Overexpression of hYVH1 caused a significant increase in polyploidy and in the G 2/M cell population, with a subsequent decrease in the G 0/G 1 population |
| 21521943 | In agreement with this, siRNA-mediated silencing of hYVH1 expression resulted in a dramatic increase in the G 0/G 1 population and susceptibility to cellular senescence |
| 21521943 | Additionally, mass spectrometry-based methods identified novel hYVH1 phosphorylation sites, including a C-terminal modification at position Ser ( 335) in the zinc-binding domain |
| 21521943 | Interestingly, phosphorylation at Ser335 regulates subcellular targeting of hYVH1 and augments the hYVH1 G 2/M phenotype |
| 21521943 | Collectively we demonstrate that hYVH1 is a novel modulator of cell cycle progression; a function mainly mediated by its C-terminal zinc-binding domain |
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