HCSGD entry for HRH3

1. General information

Official gene symbolHRH3
Entrez ID11255
Gene full namehistamine receptor H3
Other gene symbolsGPCR97 HH3R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004969Histamine receptor activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007194Negative regulation of adenylate cyclase activityIEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007612LearningIEAbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0014050Negative regulation of glutamate secretionIEAbiological_process
GO:0014053Negative regulation of gamma-aminobutyric acid secretionIEAbiological_process
GO:0014061Regulation of norepinephrine secretionIEAbiological_process
GO:0014063Negative regulation of serotonin secretionIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0042756Drinking behaviorIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043209Myelin sheathIEAcellular_component
GO:0045776Negative regulation of blood pressureIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57600892440.92906462520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0841863003
GSE13712_SHEARUp0.0812050450
GSE13712_STATICDown-0.0015310874
GSE19018Up0.0694765309
GSE19899_A1Up0.0755778787
GSE19899_A2Up0.1175206440
PubMed_21979375_A1Up0.0555353188
PubMed_21979375_A2Down-0.1237891193
GSE35957Up0.0428528122
GSE36640Up0.0651312067
GSE54402Down-0.0146655742
GSE9593Up0.0737439483
GSE43922Up0.1152283773
GSE24585Up0.0319477352
GSE37065Down-0.0457160924
GSE28863_A1Down-0.0360530270
GSE28863_A2Up0.0629409293
GSE28863_A3Up0.3427073260
GSE28863_A4Up0.1546989803
GSE48662Down-0.0196545669

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MirtazapineDB00370 APRD00685
Histamine PhosphateDB00667 APRD01015
OBE101DB05080 -
BetahistineDB06698 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.