HCSGD entry for POLG2
1. General information
| Official gene symbol | POLG2 |
|---|---|
| Entrez ID | 11232 |
| Gene full name | polymerase (DNA directed), gamma 2, accessory subunit |
| Other gene symbols | HP55 MTPOLB PEOA4 POLB POLG-BETA POLGB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000262 | Mitochondrial chromosome | TAS | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006260 | DNA replication | IEA NAS | biological_process |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | IEA NAS | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0373844041 | 0.7586002470 | 0.4364015514 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1070149437 |
| GSE13712_SHEAR | Up | 0.5994800422 |
| GSE13712_STATIC | Up | 0.6250553734 |
| GSE19018 | Down | -0.3944078577 |
| GSE19899_A1 | Up | 0.2651256844 |
| GSE19899_A2 | Up | 0.6892878759 |
| PubMed_21979375_A1 | Down | -0.0506286202 |
| PubMed_21979375_A2 | Up | 0.5095326196 |
| GSE35957 | Down | -1.1234563704 |
| GSE36640 | Down | -0.1099207832 |
| GSE54402 | Up | 0.4779555380 |
| GSE9593 | Down | -0.7200283983 |
| GSE43922 | Up | 0.3271762657 |
| GSE24585 | Up | 0.3592289847 |
| GSE37065 | Up | 0.0590441857 |
| GSE28863_A1 | Up | 0.2891852175 |
| GSE28863_A2 | Up | 0.3492693264 |
| GSE28863_A3 | Down | -0.2380500574 |
| GSE28863_A4 | Up | 0.2339805638 |
| GSE48662 | Down | -0.3339674311 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24478790 | These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association analysis identified multiple genes, including DCAF7, POLG2, CEP95, and SMURF2 at 17q23 |
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