HCSGD entry for RASSF1
1. General information
| Official gene symbol | RASSF1 |
|---|---|
| Entrez ID | 11186 |
| Gene full name | Ras association (RalGDS/AF-6) domain family member 1 |
| Other gene symbols | 123F2 NORE2A RASSF1A RDA32 REH3P21 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0007050 | Cell cycle arrest | IMP | biological_process |
| GO:0007265 | Ras protein signal transduction | IDA | biological_process |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0031398 | Positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0050821 | Protein stabilization | IDA | biological_process |
| GO:0071157 | Negative regulation of cell cycle arrest | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8292730253 | 0.2028497587 | 0.9999902473 | 0.8717075102 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3298157211 |
| GSE13712_SHEAR | Up | 0.3114476532 |
| GSE13712_STATIC | Down | -0.3023493867 |
| GSE19018 | Down | -0.1954383652 |
| GSE19899_A1 | Down | -0.1368606627 |
| GSE19899_A2 | Up | 0.0990105357 |
| PubMed_21979375_A1 | Up | 0.4447039858 |
| PubMed_21979375_A2 | Down | -0.0125901030 |
| GSE35957 | Down | -0.0320702583 |
| GSE36640 | Down | -0.0195335648 |
| GSE54402 | Down | -0.2157851793 |
| GSE9593 | Up | 0.1127872929 |
| GSE43922 | Up | 0.2907651164 |
| GSE24585 | Down | -0.3023524956 |
| GSE37065 | Down | -0.2175756633 |
| GSE28863_A1 | Down | -0.0969883220 |
| GSE28863_A2 | Up | 0.0042481424 |
| GSE28863_A3 | Down | -0.3451955543 |
| GSE28863_A4 | Down | -0.0536558418 |
| GSE48662 | Up | 0.0297036434 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT016088 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020199 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022310 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023590 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031097 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045120 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21788308 | Status of RASSF1A in uveal melanocytes and melanoma cells |
| 21788308 | RASSF1A gene, found at the 3p21 |
| 21788308 | In this study, we report that compared with melanocytes in normal choroid, RASSF1A is downregulated in uveal melanoma samples and in uveal melanoma cell lines |
| 21788308 | Moreover, methylation of the RASSF1A promoter was detected in 35 of 42 tumors (83%) and RASSF1A was also weakly expressed at the mRNA level |
| 21788308 | These data indicate that LOH at the RASSF1A locus or RASSF1A promoter methylation may partly account for the suppression of RASSF1A expression observed in uveal melanoma |
| 21788308 | 1), RASSF1A weakly reduces cell proliferation and anchorage-independent growth of uveal melanoma cells without effect on ERK1/2 activation, cyclin D1 and p27(Kip1) expression |
| 21788308 | This study explored biological functions and underlying mechanisms of RASSF1A in the ERK1/2 pathway in normal uveal melanocytes |
| 21788308 | We showed that siRNA-mediated depletion of RASSF1A increased ERK1/2 activation, cyclin D1 expression, and also decreased p27(Kip1) expression in normal uveal melanocytes |
| 21788308 | Moreover, that the depletion of RASSF1A induced senescence-associated beta-galactosidase activity and increased p21(Cip1) expression suggests that RASSF1A plays a role in the escape of cellular senescence in normal uveal melanocytes |
| 21788308 | Interestingly, we found that RASSF1A was epigenetically inactivated in long-term culture of uveal melanocytes |
| 21788308 | Taken together, these data show that depletion of RASSF1A could be an early event observed during senescence of normal uveal melanocytes and that additional alterations are acquired during malignant transformation to uveal melanoma |
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