HCSGD entry for NUDT5
1. General information
| Official gene symbol | NUDT5 |
|---|---|
| Entrez ID | 11164 |
| Gene full name | nudix (nucleoside diphosphate linked moiety X)-type motif 5 |
| Other gene symbols | YSA1 YSA1H hYSAH1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0005622 | Intracellular | NAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0009117 | Nucleotide metabolic process | NAS | biological_process |
| GO:0009191 | Ribonucleoside diphosphate catabolic process | IDA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0017110 | Nucleoside-diphosphatase activity | IEA | molecular_function |
| GO:0019144 | ADP-sugar diphosphatase activity | IDA | molecular_function |
| GO:0019303 | D-ribose catabolic process | NAS | biological_process |
| GO:0030515 | SnoRNA binding | ISS | molecular_function |
| GO:0034656 | Nucleobase-containing small molecule catabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047631 | ADP-ribose diphosphatase activity | EXP | molecular_function |
| GO:0050072 | M7G(5')pppN diphosphatase activity | ISS | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0216786444 | 0.9305570685 | 0.3546324425 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5350273582 |
| GSE13712_SHEAR | Up | 0.1322535477 |
| GSE13712_STATIC | Up | 0.0491404945 |
| GSE19018 | Up | 0.0127128313 |
| GSE19899_A1 | Up | 0.7401537524 |
| GSE19899_A2 | Up | 0.6747861812 |
| PubMed_21979375_A1 | Up | 0.9082988378 |
| PubMed_21979375_A2 | Up | 0.9875385851 |
| GSE35957 | Down | -0.4137947926 |
| GSE36640 | Up | 0.3134224207 |
| GSE54402 | Up | 0.5534394320 |
| GSE9593 | Down | -0.2034416080 |
| GSE43922 | Up | 0.5937731106 |
| GSE24585 | Up | 0.0001538340 |
| GSE37065 | Down | -0.0185501850 |
| GSE28863_A1 | Up | 0.1916340082 |
| GSE28863_A2 | Up | 0.0407232257 |
| GSE28863_A3 | Down | -0.3914372893 |
| GSE28863_A4 | Up | 0.1226047676 |
| GSE48662 | Down | -0.4345364055 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT036897 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047366 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052516 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23581889 | Human Nudix type 5 (NUDT5), a MutT-related protein, catalyzes the hydrolysis of 8-oxoGDP to 8-oxoGMP, thereby preventing the misincorporation of 8-oxoGua into RNA |
| 23581889 | To investigate the biological roles of NUDT5 in human fibroblast cells, we established cell lines with decreased levels of NUDT5 expression |
| 23581889 | These results suggested that the NUDT5 protein could play significant roles in the prevention of RNA oxidation and survival in human fibroblast cells |
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