HCSGD entry for CDC37
1. General information
| Official gene symbol | CDC37 |
|---|---|
| Entrez ID | 11140 |
| Gene full name | cell division cycle 37 |
| Other gene symbols | P50CDC37 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006605 | Protein targeting | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0031072 | Heat shock protein binding | IPI | molecular_function |
| GO:0031435 | Mitogen-activated protein kinase kinase kinase binding | IEA | molecular_function |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043422 | Protein kinase B binding | IEA | molecular_function |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
| GO:0051087 | Chaperone binding | IEA | molecular_function |
| GO:0051879 | Hsp90 protein binding | IEA | molecular_function |
| GO:0060334 | Regulation of interferon-gamma-mediated signaling pathway | IMP | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0185861783 | 0.9698428517 | 0.3337017735 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5125884859 |
| GSE13712_SHEAR | Up | 0.1273868410 |
| GSE13712_STATIC | Up | 0.0804956732 |
| GSE19018 | Up | 0.0188680100 |
| GSE19899_A1 | Up | 0.2879060167 |
| GSE19899_A2 | Up | 0.6007622073 |
| PubMed_21979375_A1 | Up | 0.7676164080 |
| PubMed_21979375_A2 | Up | 0.1112331905 |
| GSE35957 | Up | 0.0196792241 |
| GSE36640 | Up | 0.4772672706 |
| GSE54402 | Up | 0.5308556208 |
| GSE9593 | Up | 0.4368027944 |
| GSE43922 | Up | 0.1271422774 |
| GSE24585 | Down | -0.3063016566 |
| GSE37065 | Down | -0.2430357777 |
| GSE28863_A1 | Down | -0.0435558501 |
| GSE28863_A2 | Up | 0.1026961895 |
| GSE28863_A3 | Up | 0.6022340956 |
| GSE28863_A4 | Up | 0.3187450430 |
| GSE48662 | Down | -0.0810197655 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT016144 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016565 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025907 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031991 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-421 | MIMAT0003339 | MIRT039401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049255 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3200-3p | MIMAT0015085 | MIRT052815 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18258400 | CD9 antigen, MHC class I chain-related sequence A (MICA) and cell division cycle 37 homolog (CDC37) were up-regulated, and bone morphogenetic protein 4 (BMP4), dickkopf-1 (DKK1), and transcription factor 7-like 1 (TCF7L1) were down-regulated in old cells |
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