HCSGD entry for POLR3A
1. General information
| Official gene symbol | POLR3A |
|---|---|
| Entrez ID | 11128 |
| Gene full name | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa |
| Other gene symbols | ADDH HLD7 RPC1 RPC155 hRPC155 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001056 | RNA polymerase III activity | IBA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA NAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA NAS | biological_process |
| GO:0006383 | Transcription from RNA polymerase III promoter | TAS | biological_process |
| GO:0006385 | Transcription elongation from RNA polymerase III promoter | TAS | biological_process |
| GO:0006386 | Termination of RNA polymerase III transcription | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0032481 | Positive regulation of type I interferon production | TAS | biological_process |
| GO:0032549 | Ribonucleoside binding | IEA | molecular_function |
| GO:0032728 | Positive regulation of interferon-beta production | IMP | biological_process |
| GO:0045087 | Innate immune response | IMP TAS | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0025821891 | 0.9765542647 | 0.1381418699 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3476732266 |
| GSE13712_SHEAR | Up | 0.4411601156 |
| GSE13712_STATIC | Up | 0.4065866941 |
| GSE19018 | Down | -0.3236829576 |
| GSE19899_A1 | Up | 0.5786571081 |
| GSE19899_A2 | Up | 0.9774123138 |
| PubMed_21979375_A1 | Up | 1.3462597594 |
| PubMed_21979375_A2 | Up | 1.8602356390 |
| GSE35957 | Down | -0.4383744951 |
| GSE36640 | Up | 0.0176548967 |
| GSE54402 | Up | 0.6318809821 |
| GSE9593 | Up | 0.0009161939 |
| GSE43922 | Up | 1.0437773830 |
| GSE24585 | Down | -0.2721550827 |
| GSE37065 | Up | 0.1695842908 |
| GSE28863_A1 | Up | 0.7997519044 |
| GSE28863_A2 | Up | 0.8909838710 |
| GSE28863_A3 | Down | -0.1920760463 |
| GSE28863_A4 | Up | 0.0863279954 |
| GSE48662 | Up | 0.3339407254 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031770 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039125 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047708 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049495 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
