HCSGD entry for ADCY5

1. General information

Official gene symbolADCY5
Entrez ID111
Gene full nameadenylate cyclase 5
Other gene symbolsAC5 FDFM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0001973Adenosine receptor signaling pathwayIEAbiological_process
GO:0004016Adenylate cyclase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIEA ISS TAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIEAbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007195Adenylate cyclase-inhibiting dopamine receptor signaling pathwayIEAbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008179Adenylate cyclase bindingIEA ISSmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEA ISSmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
GO:0072372Primary ciliumIEA ISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92278158500.34776815090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0028789146
GSE13712_SHEARDown-0.0328674833
GSE13712_STATICDown-0.0825709750
GSE19018Down-0.0953395177
GSE19899_A1Up0.0258397537
GSE19899_A2Down-0.1349464858
PubMed_21979375_A1Down-0.0461644937
PubMed_21979375_A2Down-0.1236126690
GSE35957Up0.1309649781
GSE36640Up0.0862767153
GSE54402Up0.0570883607
GSE9593Down-0.0002013158
GSE43922Down-0.0339369202
GSE24585Down-0.1470459432
GSE37065Up0.0801437454
GSE28863_A1Down-0.5765042890
GSE28863_A2Down-0.2174004289
GSE28863_A3Up0.3154800733
GSE28863_A4Up0.0214825730
GSE48662Down-0.0097999830

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL68614CHEMBL31898O95622
CHEMBL418883CHEMBL31898O95622
CHEMBL107243CHEMBL31898O95622
CHEMBL105178CHEMBL31898O95622
CHEMBL322057CHEMBL31898O95622
CHEMBL302708CHEMBL31898O95622
CHEMBL108067CHEMBL31898O95622
CHEMBL69185CHEMBL31898O95622
CHEMBL302708CHEMBL31898O95622
CHEMBL68614CHEMBL31898O95622
CHEMBL68723CHEMBL31898O95622
CHEMBL106750CHEMBL31898O95622
CHEMBL302508CHEMBL31898O95622
CHEMBL69809CHEMBL31898O95622
CHEMBL67869CHEMBL31898O95622
CHEMBL105492CHEMBL31898O95622
CHEMBL306910CHEMBL31898O95622
CHEMBL68723CHEMBL31898O95622
CHEMBL71441CHEMBL31898O95622
CHEMBL444839CHEMBL31898O95622
CHEMBL68723CHEMBL31898O95622
CHEMBL326449CHEMBL31898O95622
CHEMBL420654CHEMBL31898O95622
CHEMBL105178CHEMBL31898O95622
CHEMBL302785CHEMBL31898O95622
CHEMBL308914CHEMBL31898O95622
CHEMBL304093CHEMBL31898O95622
CHEMBL322646CHEMBL31898O95622
CHEMBL420363CHEMBL31898O95622
CHEMBL69184CHEMBL31898O95622
CHEMBL68614CHEMBL31898O95622
CHEMBL302708CHEMBL31898O95622
CHEMBL447839CHEMBL31898O95622
CHEMBL305213CHEMBL31898O95622
CHEMBL304759CHEMBL31898O95622
CHEMBL432908CHEMBL31898O95622
CHEMBL69750CHEMBL31898O95622
CHEMBL543390CHEMBL31894O95622
CHEMBL418468CHEMBL31894O95622
CHEMBL305151CHEMBL31894O95622
CHEMBL544099CHEMBL31894O95622
CHEMBL538520CHEMBL31894O95622
CHEMBL542436CHEMBL31894O95622
CHEMBL64955CHEMBL31894O95622
CHEMBL64475CHEMBL31894O95622
CHEMBL64646CHEMBL31894O95622
CHEMBL62123CHEMBL31894O95622
CHEMBL62412CHEMBL31894O95622
CHEMBL305151CHEMBL31894O95622
CHEMBL62892CHEMBL31894O95622
CHEMBL62CHEMBL31894O95622
CHEMBL418135CHEMBL31894O95622
CHEMBL545264CHEMBL31894O95622
CHEMBL541838CHEMBL31894O95622
CHEMBL62444CHEMBL31894O95622
CHEMBL157655CHEMBL31894O95622
CHEMBL543389CHEMBL31894O95622
CHEMBL293907CHEMBL31894O95622
CHEMBL66087CHEMBL31894O95622
CHEMBL555619CHEMBL31894O95622
CHEMBL24077CHEMBL31894O95622
CHEMBL68922CHEMBL31894O95622
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  • Drugs

Name

Drug

Accession number

ColforsinDB02587 EXPT01467
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDB06843 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25077541We demonstrate that miR-17 targets both ADCY5 and IRS1, upregulating the downstream signals MKP7, FoxO3, LC3B, and HIF1alpha, and downregulating mTOR, c-myc, cyclin D1, and JNK
25077541Silencing either ADCY5 or IRS1 promoted autophagy and repressed cellular senescence and apoptosis
25077541Repression of ADCY5 by miR-17 translocated membrane-bound RGS2 into the nucleus, promoting interactions of RGS2 with HIF1alpha and the MKP7 promoter, enhancing MKP7 transcription
25077541ADCY5 repression by miR-17 also facilitated the translocation of EGFR and MKP7 from membrane into cytoplasmic and mitochondrial fractions
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