HCSGD entry for ADAMTS5
1. General information
| Official gene symbol | ADAMTS5 |
|---|---|
| Entrez ID | 11096 |
| Gene full name | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
| Other gene symbols | ADAM-TS 11 ADAM-TS 5 ADAM-TS5 ADAMTS-11 ADAMTS-5 ADAMTS11 ADMP-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008237 | Metallopeptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0008296835 | 0.4207995745 | 0.0799930403 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6638322635 |
| GSE13712_SHEAR | Up | 1.7439216976 |
| GSE13712_STATIC | Up | 0.9590177680 |
| GSE19018 | Up | 0.0405414869 |
| GSE19899_A1 | Up | 0.1269768150 |
| GSE19899_A2 | Up | 0.1998129445 |
| PubMed_21979375_A1 | Up | 1.0849535226 |
| PubMed_21979375_A2 | Up | 1.1605299717 |
| GSE35957 | Down | -2.0075975512 |
| GSE36640 | Up | 5.4815027551 |
| GSE54402 | Down | -2.1778085392 |
| GSE9593 | Down | -0.4240718949 |
| GSE43922 | Up | 0.0595886455 |
| GSE24585 | Up | 0.0189235628 |
| GSE37065 | Up | 0.3827287290 |
| GSE28863_A1 | Up | 1.6489128144 |
| GSE28863_A2 | Up | 0.1423657753 |
| GSE28863_A3 | Up | 0.3457427223 |
| GSE28863_A4 | Down | -0.2061323627 |
| GSE48662 | Up | 0.7769754026 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Batimastat | DB03880 | EXPT00627 |
| (2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide | DB06837 | - |
| N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide | DB06945 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027846 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26337541 | H2O2-senescent cells were found to possess a catabolic phenotype, mainly characterised by the up-regulation of extracellular matrix-degrading enzymes (MMP-1, -2, -9 and ADAMTS-5) and the down-regulation of their inhibitors (TIMPs), as well as of several proteoglycans, including aggrecan, the major component of the nucleus pulposus |
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